Centro Universitario de los Altos

Abstract Background: Gallstone Disease (GD) results from the interaction of genetic predisposition and environmental factors such as physical activity, diet and food habits that are characteristic of each culture. Female gender, aging, obesity and insulin resistance are strongly associated to gallstone formation. Female Mexican population presents high prevalence of obesity and GD. Hence our aim was to establish the relationship between GD, dietary constituents and nutritional factors in wo...

Introduction. Childhood obesity is a public health problem characterized by early insulin resistance (IR), inflammation, and oxidative stress. The presence of an uninterrupted low-grade inflammatory state impairs metabolic and cardiovascular health. The population is particularly susceptible to develop metabolic disorders related to increased body fat. Methods. Eighty-three adolescents were recruited and grouped according to HOMA-IR and BMI in either with or without IR and obese or no...

Obesity is a metabolic disorder that has a multifactorial etiology and affects millions of people worldwide. Ghrelin, a hormone coded by the GHRL gene, plays a role in human body composition and appetite. Single nucleotide polymorphisms (SNPs) of the GHRL gene have been associated with obesity and metabolic disorders. To evaluate the association of A-604G SNP of GHRL promoter region with serum ghrelin levels and the risk of obesity in a Mexican population. Two hundred and fifty individuals w...

The purpose of this study was to assess the interaction and mechanisms of action of the paracetamol‐tapentadol combination in the formalin‐induced pain model in mice. Paracetamol (56.23–562.3 mg/kg, i.p.) or tapentadol (1–10 mg/kg, i.p.) were administered 15 min prior the intraplantar injection of formalin. The ED50 value of each drug was determined through the dose–response curves. The ED50 values were used to calculate the combinations in three fixed proportions (1:1, 1:3, and 3:1). Naloxon...

Abstract Introduction: Osteocalcin has been shown to have an inverse relationship with blood glucose, insulin resistance and adiposity. Objective: To determine osteocalcin normal serum concentration in Mexican healthy adults and compare it with values reported in other populations. Method: Carboxylated and undercarboxylated osteocalcin serum concentrations were determined in 100 healthy adults by means of enzyme immunoassay; osteocalcin total concentration was calculated. A descriptive com...

Los sistemas de producción se caracterizan por su diversidad, diferentes condiciones de producción, de acuerdo con la orientación de la producción, adaptados a un amplio rango de situaciones, vinculados con la tradición y el territorio. La ganadería doble pro-pósito, por sus características, representa una actividad relevante para el desarrollo lo-cal, ya que tradicionalmente se produce leche y carne y, la venta de leche es una fuente importante de ingresos para la economía de las familias ru...

RESUMEN: Los resultados obtenidos de un ciclo productivo de que compreden un año completo de acuerdo al manejo llevado a cabo en la Granja Caprina de Tecolotlán, Jalisco; se procedió a pesar los cabritos al nacimiento y al destete el cual se realizó a los 120 días después de nacidos, en ambas razas esto para poder determinar si existen diferencias significativas entre la raza Nubia y Toggenburg con relación a la conversión alimento carne y de esta forma determinar cual raza adquiere mayor p...

RESUMEN Este artículo busca precisar cuáles fueron los factores que permitieron a una mujer mexicana de origen campesino, con estudios incompletos de educación primaria, llegar a ser una emprendedora exitosa. El tema medular del artículo trata pues de la formación no universitaria de esta mujer emprendedora, de las dificultades que experimentó para lograr ser emprendedora y de los factores que contribuyeron a alcanzar su meta. El presente estudio sigue el método del relato de vida, poco aplic...

El bienestar de los animales se ha desarrollado rápidamente como disciplina científica desde la década de los años ochenta. Durante los últimos años en México el tema del bienestar animal y el ejercicio profesional médico veterinario se han enfrentado al problema de que en algunos campos de su competencia a los profesionales se les exige un conocimiento que no adquirieron en su formación como especialistas. Es por ello, que el presente libro pretende dotar de conceptos y conocimientos a los ...

La fiesta tradicional y religiosa en honor del Señor de la Misericordia que se realiza en la ciudad de Ocotlán, Jalisco, comienza el 20 de septiembre y termina el 3 de octubre. Durante catorce días convergen con la fiesta religiosa la feria del pueblo y la celebración del mes de la patria que promueve el Ayuntamiento por medio de actividades deportivas, artísticas y recreativas. La fiesta se compone de tres dimensiones estructurales: religiosa, cívica y comercial. Cada una de ellas posee u...

Cuadernos de Los Altos, revista del Centro Universitario de Los Altos de la Universidad de Guadalajara, es una publicación semestral que difunde textos derivados de la práctica investigativa y académica sobre cualquiera de las disciplinas que conforman el amplio campo del espectro del conocimiento. Los trabajos firmados son de exclusiva responsabilidad de los autores. En la selección de los textos el comité editorial se auxiliará de la dictaminación de especialistas nacionales y extranjeros.

Aprender a emprender es ya un tema relevante que en la actualidad valdría la pena ser integrado en la educación mexicana y el emprendimiento ser considerado un valor transformador que forme parte de sus pilares pedagógicos. Tomar en cuenta las habilidades y aptitudes de cada uno de los individuos para que, siendo líderes, innovadores, creativos y visionarios, se preparen para una sociedad trascendental. Así entonces, la educación es el principal medio para lograr que los estudiantes se formen...

Abstract Introduction: Patients with HIV+ often present lipid disturbances. The role of ghrelin and obestatin in these lipid disturbances is not clear. The effect of antiretroviral (ART) drugs on those molecules is also unknown. This study measured ghrelin and obestatin levels, as well as metabolic markers, in patients with HIV+ before and after 36 weeks of ART. Material and methods: Twenty HIV-positive, ART-naïve patients who started a scheme con-sisting of tenofovir/emtricitabine + lopinavi...

Background Persistent high risk HPV infection can lead to cervical cancer, the second most common malignant tumor in women worldwide. NK cells play a crucial role against tumors and virus-infected cells through a fine balance between activating and inhibitory receptors. Expression of triggering receptors NKp30, NKp44, NKp46 and NKG2D on NK cells correlates with cytolytic activity against tumor cells, but these receptors have not been studied in cervical cancer and precursor lesions. The aim ...

Patients with cervical cancer (CxCa) typically present an infiltrate of tumor-associated macrophages, which is associated with a poor prognosis. We found that CxCa cell lines (HeLa, SiHa, and C-33A) secreted factors involved in regulating tumor growth including IL-6, IL-4, PDGFAA, HGF, VEGF, ANG-2, and TGF-β3. We assessed the effects of culture supernatants from these cell lines on macrophages derived from the THP-1 cell line. Macrophages treated with culture supernatants from CxCa cells deve...

The objectives of the present study were to assess the effect of permanent contact of teasers without copulation on the interval from controlled internal drug release (CIDR) removal to estrus onset, estrus duration, ovulation time, number of ovulations, and interval from CIDR removal to ovulation time on estrus-synchronized Boer goats. During the fall season, a controlled randomized design experiment with two groups, control (CON; n = 18) and treatment (TRE; n = 18), was performed. The TRE gr...

Abstract Introduction: Long bones fractures are responsible for prolonged periods of incapacity and economic losses. New therapies for shortening the time of consolidation are needed. Thus, the purpose of this clinical study was to evaluate the efficacy of noise plus weight-bearing over the bone consolidation of tibial shaft fractures. Methods: In this clinical trial, 12 patients with tibial shaft fractures were recruited during a 24-month period. Participants were treated with intramedulla...

Murine leprosy, caused by Mycobacterium lepraemurium (MLM), is a chronic disease that closely resembles human leprosy. Even though this disease does not directly involve the nervous system, we investigated a possible effect on working memory during this chronic infection in Balb/c mice. We evaluated alterations in the dorsal region of the hippocampus and measured peripheral levels of cytokines at 40, 80, and 120 days post-infection. To evaluate working memory, we used the T-maze while a morph...

Cervical cancer (CC) is the second most common cancer among women worldwide. Infection with human papillomavirus (HPV) is the main risk factor for developing CC. Macrophages are important immune effector cells; they can be differentiated into two phenotypes, identified as M1 (classically activated) and M2 (alternatively activated). Macrophage polarization exerts profound effects on the Toll-like receptor (TLR) profile. In this study, we evaluated whether the supernatant of human CC cells HeLa...