http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/47 2026-01-21T07:14:22Z 2026-01-21T07:14:22Z Ayala Madrigal, María de la Luz González Mercado, Anahí Gutiérrez Angulo, Melva Martínez López, Erika Moreno Ortiz, José Miguel Peregrina Sandoval, Jorge Ramírez Ramírez, Ruth http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1600 2024-02-13T21:51:56Z 2023-03-01T00:00:00Z

Title: Capítulo 2. Mecanismos genético-moleculares involucrados en el desarrollo del cáncer y su relación con el estilo de vida Authors: Ayala Madrigal, María de la Luz; González Mercado, Anahí; Gutiérrez Angulo, Melva; Martínez López, Erika; Moreno Ortiz, José Miguel; Peregrina Sandoval, Jorge; Ramírez Ramírez, Ruth Abstract: El cáncer constituye un problema de salud pública. En el año 2020, una de cada seis muertes en el mundo ocurrió por esta causa, siendo los más frecuentes: cáncer de mama, pulmón, colorrectal y de próstata, manteniéndose el mismo orden en México. En este capítulo se describen los factores genéticos y ambientales, así como los mecanismos moleculares que dan origen al cáncer, se incluyen los síndromes hereditarios relacionados con los tipos de cáncer más frecuentes y los tratamientos aprobados basados en los biomarcadores moleculares accionables. El conocimiento de los fundamentos genético-moleculares del cáncer contribuye de forma sustancial a su abordaje médico; por otra parte, identificar los factores ambientales y estilo de vida que inciden en su desarrollo es fundamental para disminuir el riesgo de presentar cáncer. Abstract Cancer is a public health problem. In 2020, one in six deaths in the world occurred from this cause, among the most frequent are: breast cancer, lung cancer, colorectal and prostate cancer, maintaining the same order in Mexico. This chapter describes the genetic and environmental factors as well as their molecular mechanisms that give rise to cancer, including the hereditary syndromes related to the most frequent types of cancer and the approved treatments based on actionable molecular biomarkers. Knowledge of the genetic-molecular basis of cancer contributes substantially to its medical approach; on the other hand, identifying the environmental and lifestyle factors that affect its development is essential to reduce the risk of developing cancer. Description: Capítulo

2023-03-01T00:00:00Z Torres Romero, Julio Cesar Lara Riegos, Julio César Estrella Parra, Edgar Antonio Fernández Sánchez, Verónica Arana Argáez, Víctor Ermilo Uc Colli, Sushally Peña Rico, Miguel Ángel Ramírez Camacho, Mario Alberto Ponce Regalado, María Dolores Álvarez Sánchez, María Elizbeth http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1376 2023-10-05T18:06:58Z 2021-06-01T00:00:00Z

Title: Lipoproteomics: Methodologies and Analysis of Lipoprotein-Associated Proteins along with the Drug Intervention Authors: Torres Romero, Julio Cesar; Lara Riegos, Julio César; Estrella Parra, Edgar Antonio; Fernández Sánchez, Verónica; Arana Argáez, Víctor Ermilo; Uc Colli, Sushally; Peña Rico, Miguel Ángel; Ramírez Camacho, Mario Alberto; Ponce Regalado, María Dolores; Álvarez Sánchez, María Elizbeth Abstract: Lipoproteins are specialized particles involved in the transport and distribution of hydrophobic lipids, as cholesterol and triglycerides, throughout the body. The lipoproteins exhibit a basic spherical shape as complexes of lipids and proteins, and these latter are known as apolipoproteins. Initially, the proteins associated with lipoproteins were recognized as integral or peripheral proteins that only maintain the dynamics and metabolism of lipoproteins. However, there exist many studies on different lipoproteins evidencing that the quantity and type of apolipoproteins and lipoprotein-associated proteins are diverse and could be associated with different lipoprotein function outcomes. Here, we summarized recent processes in the determination of apolipoproteins and lipoprotein-associated proteins profiles through a proteomic approach, analyzing the major methods available and are used to achieve this. We also discuss the relevance of these lipoproteomic analyses on the human disease outcomes. Description: Capítulo

2021-06-01T00:00:00Z Barbosa Mendez, Susana Becerril Villanueva, Luis Enrique Ponce Regalado, María Dolores Salazar Juárez, Alberto http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1375 2022-07-12T17:18:22Z 2021-01-01T00:00:00Z

Title: Mirtazapine: Multitarget strategies for treating substance use disorder and depression Authors: Barbosa Mendez, Susana; Becerril Villanueva, Luis Enrique; Ponce Regalado, María Dolores; Salazar Juárez, Alberto Abstract: Abstract For the past decades, several antidepressants have been explored as possible therapeutic drugs to relieve SUD. Mirtazapine is an approved atypical medication for the treatment of moderate to severe MDD. However, several studies indicated that the dosage program, consisting of a dose of 30mg/kg of mirtazapine, administered for 30 days or more during the early phase of withdrawal does not cause sedation, leads to a decrease in the symptoms of depression and anxiety during prolonged periods of drug withdrawal, and generates a permanent reduction (even in the absence of mirtazapine) of the behavioral effects induced by simple or combined drug use in rodents and humans. These studies support the efficacy of mirtazapine in reducing the behavioral reinforcing effect induced by a wide variety of drugs. Mirtazapine meets the characteristics of a multitarget drug, which suggests that it can be used either in future clinical trials or as a key molecule design new drugs. Description: Capítulo

2021-01-01T00:00:00Z Becerril Villanueva, Luis Enrique Ponce Regalado, María Dolores Pérez Sánchez, Gilberto Salazar Juárez, Alberto Arreola, Rodrigo Álvarez Sánchez, María Elizbeth Juárez Ortega, Mario Falfán Valencia, Ramcés Hernández Pando, Rogelio Morales Montor, Jorge Pavón, Lenin Rojas Espinosa, Oscar http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/894 2023-09-11T23:25:40Z 2018-06-13T00:00:00Z

Title: Chronic infection with Mycobacterium lepraemurium induces alterations in the hippocampus associated with memory loss Authors: Becerril Villanueva, Luis Enrique; Ponce Regalado, María Dolores; Pérez Sánchez, Gilberto; Salazar Juárez, Alberto; Arreola, Rodrigo; Álvarez Sánchez, María Elizbeth; Juárez Ortega, Mario; Falfán Valencia, Ramcés; Hernández Pando, Rogelio; Morales Montor, Jorge; Pavón, Lenin; Rojas Espinosa, Oscar Abstract: Murine leprosy, caused by Mycobacterium lepraemurium (MLM), is a chronic disease that closely resembles human leprosy. Even though this disease does not directly involve the nervous system, we investigated a possible effect on working memory during this chronic infection in Balb/c mice. We evaluated alterations in the dorsal region of the hippocampus and measured peripheral levels of cytokines at 40, 80, and 120 days post-infection. To evaluate working memory, we used the T-maze while a morphometric analysis was conducted in the hippocampus regions CA1, CA2, CA3, and dentate gyrus (DG) to measure morphological changes. In addition, a neurochemical analysis was performed by HPLC. Our results show that, at 40 days post-infection, there was an increase in the bacillary load in the liver and spleen associated to increased levels of IL-4, working memory deterioration, and changes in hippocampal morphology, including degeneration in the four subregions analyzed. Also, we found a decrease in neurotransmitter levels at the same time of infection. Although MLM does not directly infect the nervous system, these findings suggest a possible functional link between the immune system and the central nervous system.

2018-06-13T00:00:00Z