DSpace Community:http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/8732026-01-22T22:08:08Z2026-01-22T22:08:08ZPlant-Based Extracts as Reducing, Capping, and Stabilizing Agents for the Green Synthesis of Inorganic NanoparticlesVillagrán, ZuamíAnaya Esparza, Luis MiguelVelázquez Carriles, Carlos ArnulfoSilva Jara, Jorge ManuelRuvalcaba Gómez, José MartínAurora Vigo, Edward F.Rodríguez Lafitte, ErnestoRodríguez Barajas, NoéBalderas León, IvánMartínez Esquivias, Fernandohttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/17282025-08-19T22:08:10Z2024-05-01T00:00:00ZTitle: Plant-Based Extracts as Reducing, Capping, and Stabilizing Agents for the Green Synthesis of Inorganic Nanoparticles
Authors: Villagrán, Zuamí; Anaya Esparza, Luis Miguel; Velázquez Carriles, Carlos Arnulfo; Silva Jara, Jorge Manuel; Ruvalcaba Gómez, José Martín; Aurora Vigo, Edward F.; Rodríguez Lafitte, Ernesto; Rodríguez Barajas, Noé; Balderas León, Iván; Martínez Esquivias, Fernando
Abstract: The synthesis of inorganic nanoparticles for diverse applications is an active research area that involves physical and chemical methods, which typically are expensive, involve hazardous chemical reagents, use complex equipment and synthesis conditions, and consume large amounts of time and energy. Thus, green synthesis methods have emerged as eco-friendly and easy alternatives for inorganic nanoparticle synthesis, particularly the use of plant-based extracts from fruit juice, leaves, seeds, peel, stem, barks, and roots, which act as reducing, capping, and stabilizing agents, contributing to the Sustainable Development Goals and circular economy principles. Therefore, diverse inorganic nanoparticles have been synthesized using plant-based extracts, including gold, silver, titanium dioxide, zinc, copper, platinum, zirconium, iron, selenium, magnesium, nickel, sulfur, cobalt, palladium, and indium nanoparticles, which exhibit different biological activities such as antioxidant, antimicrobial, dye degradation, cytotoxic, analgesic, sedative, wound-healing, skin protection, sensor development, and plant-growth-promoting effects. Therefore, this review summarizes the advantages and limitations of plant-based extracts as reducing, capping, and stabilizing agents for inorganic nanoparticle green synthesis.
Description: Artículo2024-05-01T00:00:00ZThe Inflammatory Response in Metabolic SyndromeMartínez Pérez, Luz AndreaGonzález Sánchez, Grecia DenisseMartínez Esquivias, FernandoBecerra Ruiz, Julieta SaraíGuzmán Flores, Juan Manuelhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/17262025-08-19T22:07:51Z2025-06-01T00:00:00ZTitle: The Inflammatory Response in Metabolic Syndrome
Authors: Martínez Pérez, Luz Andrea; González Sánchez, Grecia Denisse; Martínez Esquivias, Fernando; Becerra Ruiz, Julieta Saraí; Guzmán Flores, Juan Manuel
Abstract: Metabolic syndrome (MS) encompasses a cluster of metabolic disorders that significantly increase the risk of developing cardiovascular diseases and type 2 diabetes mellitus. While the precise etiology of MS remains unclear, it is widely recognized as a multifactorial condition influenced by environmental, lifestyle, and genetic factors. Inflammation, a fundamental physiological response designed to maintain homeostasis, plays a central role in MS. When the body detects foreign substances or cellular stress, the immune system is activated, synthesizing signaling molecules, such as cytokines and chemokines. However, prolonged or dysregulated immune activation can result in chronic low-grade inflammation, a hallmark of MS. This persistent inflammatory state contributes to the pathophysiology of MS by promoting insulin resistance, endotelial dysfunction, and adipose tissue remodeling. The diagnostic criteria for MS, including central obesity, dyslipidemia, hyperglycemia, and hypertension, are all associated with inflammatory processes mediated by the activation of both innate and adaptive immune systems.
This review explores the intricate relationship between each diagnostic criterion of MS and the inflammatory response. By delving into the immunological mechanisms underpinning MS, we aim to understand how inflammation links metabolic dysregulation to disease progression comprehensively. This knowledge could pave the way for targeted therapeutic interventions and lifestyle modifications to mitigate the global burden of MS.
Description: Artículo2025-06-01T00:00:00ZOnco-Ontogeny of Squamous Cell Cancer of the First Pharyngeal Arch DerivativesSat Muñoz, DanielBalderas Peña, Luz María AdrianaGómez Sánchez, EduardoMartínez Herrera, Brenda EugeniaTrujillo Hernández, BenjamínQuiroga Morales, Luis AarónSalazar Páramo, MarioDávalos Rodríguez, Ingrid PatriciaNuño Guzmán, Carlos M.Velázquez Flores, Martha CeciliaOchoa Plascencia, Miguel RicardoMuciño Hernández, María IvetteIsiordia Espinoza, Mario AlbertoMireles Ramírez, Mario AlbertoHernández Salazar, Eduardohttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/17122025-02-28T01:42:48Z2024-09-01T00:00:00ZTitle: Onco-Ontogeny of Squamous Cell Cancer of the First Pharyngeal Arch Derivatives
Authors: Sat Muñoz, Daniel; Balderas Peña, Luz María Adriana; Gómez Sánchez, Eduardo; Martínez Herrera, Brenda Eugenia; Trujillo Hernández, Benjamín; Quiroga Morales, Luis Aarón; Salazar Páramo, Mario; Dávalos Rodríguez, Ingrid Patricia; Nuño Guzmán, Carlos M.; Velázquez Flores, Martha Cecilia; Ochoa Plascencia, Miguel Ricardo; Muciño Hernández, María Ivette; Isiordia Espinoza, Mario Alberto; Mireles Ramírez, Mario Alberto; Hernández Salazar, Eduardo
Abstract: Head and neck squamous cell carcinoma (H&NSCC) is an anatomic, biological, and genetic complex disease. It involves more than 1000 genes implied in its oncogenesis; for this review, we limit our search and description to the genes implied in the onco-ontogeny of the derivates from the first pharyngeal arch during embryo development. They can be grouped as transcription factors and signaling molecules (that act as growth factors that bind to receptors). Finally, we propose the term embryo-oncogenesis to refer to the activation, reactivation, and use of the genes involved in the embryo’s development during the oncogenesis or malignant tumor invasion and metastasis events as part of an onco-ontogenic inverse process.
Description: Artículo2024-09-01T00:00:00ZEvaluation of Dactylopius opuntiae Extract for Xanthine Oxidase Inhibition and Serum Uric Acid Reduction in a Hyperuricemic Mouse ModelAragon Martinez, Othoniel H.González Chávez, Marco M.Galicia Cruz, Othir G.Méndez Gallegos, Santiago de J.Isiordia Espinoza, Mario AlbertoMartinez Morales, Flaviohttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/17112025-02-28T01:42:34Z2024-11-01T00:00:00ZTitle: Evaluation of Dactylopius opuntiae Extract for Xanthine Oxidase Inhibition and Serum Uric Acid Reduction in a Hyperuricemic Mouse Model
Authors: Aragon Martinez, Othoniel H.; González Chávez, Marco M.; Galicia Cruz, Othir G.; Méndez Gallegos, Santiago de J.; Isiordia Espinoza, Mario Alberto; Martinez Morales, Flavio
Abstract: Background/Objectives: Current urate-lowering therapies may cause serious side effects in patients. Thus, alternative treatments are needed to regulate uric acid (UA) levels in patients with hyperuricemia associated with kidney injury, and natural antioxidant sources have demonstrated utility in this field. For the first time, our study evaluated the effects of an extract of Dactylopius opuntiae insects on the levels of xanthine oxidase (XO) enzymes and synthetic free radicals in vitro and in vivo. Methods: Insects were bred and collected, and two different extracts (D1 and D2) were obtained. For both extracts, XO inhibition and radical scavenging assays were performed. Subsequently, serum purine levels and renal markers were quantified in male BALB/c mice who received a hyperuricemia induction using potassium oxonate, hypoxanthine, and gentamicin. Results: The D2 extract contained 18,037.7 µg/mL of carminic acid, inhibited 53.2% of XO activity at one concentration, and showed IC50 values of 18,207.8 and 5729.6 µg/mL against ABTS and DPPH radicals, respectively. D2 administration reduced serum UA and creatinine levels and prevented an increase in kidney weight and reduction in renal antioxidant capacity caused by hyperuricemia induction and allopurinol use in mice. Despite the satisfactory antioxidant results obtained in vitro, the D1 extract killed the animal models due to its citric acid content. Conclusions: The D2 insect extract can be used as an effective urate-lowering therapy when the increased level of serum uric acid is due to kidney damage.
Description: Artículo2024-11-01T00:00:00Z