http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/593 2026-04-07T07:32:56Z http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1479 Title: Local Tramadol Improves the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis Authors: Gómez Sánchez, Eduardo; Franco de la Torre, Lorenzo; Bologna Molina, Ronell Eduardo; Molina Frechero, Nelly; Serafín Higuera, Nicolás Addiel; Hernández Gómez, Adriana; Alonso Castro, Ángel Josabad; Sat Muñoz, Daniel; Isiordia Espinoza, Mario Alberto Abstract: Abstract Symptomatic irreversible pulpitis is a painful clinical condition with a broad inflammatory component. Dental anesthesia in these patients is affected by the inflammatory process, reporting a high incidence of anesthesia failure. The aim of this systematic review and meta-analytical evaluation was to determine the effect of pre-treatment with tramadol in patients with symptomatic irreversible pulpitis, as well as for pain control and adverse effects. This study was registered in PROSPERO (ID: CRD42021279262). PubMed was consulted to identify clinical investigations comparing tramadol and placebo/local anesthetics in patients with symptomatic irreversible pulpitis. Data about the anesthesia, pain control, and adverse effects were extracted. Both the anesthetic success index and the adverse effects of local tramadol and placebo were compared with the Mantel–Haenszel test and odds ratio. Data analysis showed that the local administration of tramadol increased the anesthetic success rate when compared to placebo in patients with symptomatic irreversible pulpitis (n = 228; I2 = 0; OR = 2.2; 95% CIs: 1.30 to 3.79; p < 0.004). However, local administration of tramadol increased the risk of adverse effects when compared to placebo/local anesthetics (n = 288; I2 = 0; OR = 7.72; 95% CIs: 1.37 to 43.46; p < 0.02). In conclusion, this study shows that the local administration of tramadol increases the anesthetic success index when compared to placebo in patients with symptomatic irreversible pulpitis. Description: Artículo 2022-10-01T00:00:00Z http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1467 Title: Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis Authors: Franco de la Torre, Lorenzo; Gómez Sánchez, Eduardo; Serafín Higuera, Nicolás Addiel; Alonso Castro, Ángel Josabad; López Verdín, Sandra; Molina Frechero, Nelly; Granados Soto, Vinicio; Isiordia Espinoza, Mario Alberto Abstract: Abstract Inferior alveolar nerve block (IANB) has a high failure rate in subjects with symptomatic irreversible pulpitis (SIP). It has been suggested that drugs with anti-inflammatory activity could improve the efficacy of the anesthetic used for IANB. The aim of this study was to assess the effect of dexamethasone on the success of dental anesthesia in patients with SIP. An information search was performed using PubMed and Google Scholar. The risk of bias of the included studies was evaluated with the Cochrane Collaboration’s risk-of-bias tool. The anesthetic success rate, pain intensity (VAS), and adverse effects were extracted. Data were analyzed using the Mantel–Haenszel test and odds ratio or the inverse variance and standardized mean difference. Dexamethasone increased the anesthetic success in comparison with placebo (n = 502; p < 0.001; OR = 2.59; 95% CIs: 1.46 to 4.59). Moreover, patients who were given dexamethasone had lower pain scores at 6 h (n = 302; p < 0.001; MD= −1.43; 95% CIs: −2.28 to −0.58), 12 h (n = 302; p < 0.0001; MD = −1.65; 95% CIs: −2.39 to −0.92), and 24 h (n = 302; p < 0.0008; MD = −1.27; 95% CIs: −2.01 to −0.53) when compared with placebo. In conclusion, the systemic administration of dexamethasone increases the anesthetic success rate and improves pain management in patients with SIP. Description: Artículo 2022-07-01T00:00:00Z http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1454 Title: Efficacy of Methylprednisolone Compared to Other Drugs for Pain, Swelling, and Trismus Control after Third Molar Surgery: A Meta-Analysis Authors: González Morelos, Mariana; Franco de la Torre, Lorenzo; Franco González, Diana Laura; Gómez Sánchez, Eduardo; Alonso Castro, Ángel Josabad; Molina Frechero, Nelly; Anaya Esparza, Luis Miguel; Isiordia Espinoza, Mario Alberto Abstract: Abstract The purpose of this systematic review and meta-analysis was to assess the efficacy of methylprednisolone compared to other drugs to control postoperative complications following third molar surgery. PubMed and Google Scholar were used for article searching. Thereafter, the trials meeting the selection criteria and with high methodological quality, according to the Cochrane Collaboration’s risk of bias tool, were included in this study. The inverse variance test and mean difference using the Review Manager Software 5.3 for Windows were used to carry out data analysis. Qualitative analysis shows that methylprednisolone is more effective than NSAIDs, but inferior to dexamethasone, for controlling postoperative complications after third molar removal. The quantitative analysis showed no statistical difference for pain control, while trismus evaluation showed a statistical difference after 7 postoperative days in favor of methylprednisolone, when compared to other drugs. In conclusion, methylprednisolone was more effective for trismus control compared to other drugs after lower third molar surgery. Description: Artículo 2022-06-01T00:00:00Z http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1453 Title: Bioactive compounds identification and physicochemical characterization from Nopalea cochenillifera (L.) Salm-Dyck cladodes flour Authors: Fabela Illescas, Héctor Enrique; Castro Mendoza, Marisol Patricia; Montalvo González, Efigenia; Anaya Esparza, Luis Miguel; Vargas Torres, Apolonio; Betanzos Cabrera, Gabriel; Hernández Uribe, Juan Pablo Abstract: ABSTRACT Nopalea cochenillifera (L.) Salm-Dyck is a scarcely studied cactus; its characterization contributes to identify the bioactive compounds it contains and its functional properties, which will allow the generation of information on potential uses and applications. The aim of this work was to physicochemically characterize N. cochenillifera cladodes flour and identify the phenolic compounds it contains. In general, N. cochenillifera flour is low in calories (337 kcal/100 g) with high total dietary fiber content (18.41%). In addition, it exhibits good water (11.04%) and oil (2.05%) absorption capacity, while swelling capacity was 25 mL/g DW. The soluble and hydrolyzable polyphenols content were 207.92 and 647.99 mg EAG/100 g DW, respectively. In addition, they showed antioxidant activity by DPPH• (15.28 mmol TE/g DW), FRAP (20.97 mmol TE/g DW), and ABTS•+ (51.31 mmol TE/g DW) methods. Furthermore, six phenolic acids (gallic, ferulic, chlorogenic, p-coumaric, syringic, and neochlorogenic) were identified by HPLC. According to the results, N. cochenillifera cladodes flour is an important source of fiber and bioactive compounds with interesting functional properties. In this context, N. cochenillifera flour could be used as an ingredient in the formulation of functional foods. However, further, studies are needed on the shelf life and optimizing its preservation process, transformation, and functional potential. RESUMEN Nopalea cochenillifera (L.) Salm-Dyck es un nopal poco estudiado, su caracterización contribuye a identificar los compuestos bioactivos y las propiedades funcionales que posee, esto permitirá, generar información sobre potenciales usos y aplicaciones. El objetivo del trabajo fue caracterizar fisicoquímicamente la harina de cladodios de N. cochenillifera e identificar los compuestos bioactivos que contiene. En general, la harina de N. cochenillifera tiene bajas calorías (337 kcal/100 g ) con alto contenido de fibra dietética (18.41%). Además, exhibe buena capacidad de absorción de agua (11.04%) y aceite (2.05%), mientras que la capacidad de hinchamiento fue de 25 mL/g base seca (bs). El contenido de fenoles solubles y polifenoles hidrolizables fueron 207.92 y 647.99 mg EAG/100 g bs respectivamente. Además, de presentar actividad antioxidante por DPPH• (15.28 mmol TE/g bs), FRAP (20.97 mmol TE/g bs) y ABTS•+ (51.31 mmol TE/g bs), se identificaron cinco ácidos fenólicos. De acuerdo con los resultados, la harina de N. cochenillifera es una fuente importante de fibra y compuestos bioactivos con propiedades funcionales. En este contexto, podría ser utilizada como ingrediente funcional en la formulación de otros alimentos. Sin embargo, son necesarios futuros estudios sobre la vida útil de la harina, así como la optimización de su proceso de conservación, transformación y potencial funcional. Description: Artículo 2022-04-01T00:00:00Z