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Title: Serum levels of chemokines in adolescents with major depression treated with fluoxetine
Authors: De la Peña, Francisco Javier
Cruz Fuentes, Carlos
Palacios, Lino
Girón Pérez, Manuel Iván
Medina Rivero, Emilio
Ponce Regalado, María Dolores
Álvarez Herrera, Samantha
Pérez Sánchez, Gilberto
Becerril Villanueva, Enrique
Maldonado García, José Luis
Pavón, Lenin
Jiménez Martínez, María C
Keywords: adolescents
major depression
inferon gamma-induced preitin-10
Issue Date: 19-Aug-2020
Publisher: Baishideng Publishing Group Inc.
Citation: de la Peña FR, Cruz Fuentes C, Palacios L, Girón Pérez MI, Medina Rivero E, Ponce Regalado MD, Álvarez Herrera S, Pérez Sánchez G, Becerril Villanueva E, Maldonado García JL, Jiménez Martínez MC, Pavón L. Serum levels of chemokines in adolescents with major depression treated with fluoxetine. World J Psychiatr 2020; 10(8): 175-186
Series/Report no.: World Journal of W J P Psychiatry;10(8): 175-186
Abstract: BACKGROUND Major depressive disorder (MDD) is a global health issue that affects 350 million people of all ages. Although between 2% and 5.6% of affected individuals are adolescents, research on young patients is limited. The inflammatory response contributes to the onset of depression, and in adult MDD patients, symptom severity has been linked to chemokine levels. AIM To determine the differences in circulatory levels of chemokines in healthy volunteers (HVs) and adolescents with MDD, and assess the changes induced by fluoxetine consume. METHODS The 22 adolescents with MDD were monitored during the first 8 wk of clinical follow-up and clinical psychiatric evaluation was done using the Hamilton depresión rating scale (HDRS). The serum levels of monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β, interleukin (IL)-8, interferon gamma-induced protein (IP)-10, and eotaxin were measured in patients and HVs. RESULTS In all cases, significant differences were detected in circulating chemokine levels between patients before treatment and HVs (P < 0.0001). All chemokines decreased at 4 wk, but only MCP-1 and IL-8 significantly differed (P < 0.05) between 0 wk and 4 wk. In the patients, all chemokines rose to their initial concentrations by 8 wk vs 0 wk, but only IP-10 did so significantly (P < 0.05). All patients experienced a significant decrease in HDRS scores at 4 wk (P < 0.0001) and 8 wk (P < 0.0001) compared with 0 wk. CONCLUSION Despite the consumption of fluoxetine, patients had significantly higher chemokine levels, even after considering the improvement in HDRS score. The high levels of eotaxin, IP-10, and IL-8 partially explain certain aspects that are affected in MDD such as cognition, memory, and learning.
ISSN: 2220-3206
Appears in Collections:3210 Artículos

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