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Title: Somatic deletion of KDM1A/LSD1 gene is associated to advanced colorectal cancer stages
Authors: Ramírez Ramírez, Ruth
Gutiérrez Angulo, Melva
Peregrina Sandoval, Jorge
Moreno Ortiz, José Miguel
Franco Topete, Ramon Antonio
Cerda Camacho, Felipe de Jesús
Ayala Madrigal, María de la Luz
Keywords: KDM1A/LSD1
colorectal cancer
Issue Date: Feb-2020
Publisher: BMJ Journals
Citation: Ramírez Ramírez R, Gutiérrez Angulo M, Peregrina Sandoval J, et al. J Clin Pathol 2020;73:107–111.
Series/Report no.: Journal of Clinical Pathology;February 2020 - Volume 73 - 2
Abstract: Abstract Aims: KDM1A/LSD1 and ZNF217 are involved in a protein complex that participates in transcriptional regulation. ZNF217 has been analysed in numerous cancers and its amplification has been associated with advanced stages of disease; however, a similar role for KDM1A/LSD1 has not been uncovered. In this study, we estimated the number of KDM1A/LSD1 and ZNF217 gene copies in tissue samples from patients diagnosed with colorectal cancer (CRC), as well as its association with clinicopathological features in patients with CRC. Methods: Paraffin-embedded tumour samples from 50 patients with CRC with a histopathological diagnosis of CRC were included. The number of copies of KDM1A/LSD1 and ZNF217 genes was determined by fluorescence in situ hybridisation (FISH). We also analysed the association between copy numbers of selected genes and clinicopathological data based on multivariate analysis. Results: Deletion of the KDM1A/LSD1 gene occurred in 19 samples (38%), whereas ZNF217 gene amplification was identified in 11 samples (22%). We found a significant association between lymph node metastasis or advanced tumour stage and KDM1A/LSD1 gene deletion (p value=0.0003 and p value=0.011, respectively). Conclusions: KDM1A/LSD1 gene deletion could be considered a novel prognostic biomarker of late-stage CRC.
ISSN: 0021-9746
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