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Title: A Review of the Effects of Gold, Silver, Selenium, and Zinc Nanoparticles on Diabetes Mellitus in Murine Models
Authors: Martínez Esquivias, Fernando
Guzmán Flores, Juan Manuel
Pérez Larios, Alejandro
Rico, José Luis
Becerra Ruiz, Julieta Sarai
Keywords: metal nanoparticles
Issue Date: Feb-2021
Publisher: Bentham Science
Citation: Martínez Esquivias F., Guzmán Flores J.M., Pérez Larios A., Rico J.L. and Becerra Ruiz J.S. (2021). “A Review of the Effects of Gold, Silver, Selenium, and Zinc Nanoparticles on Diabetes Mellitus in Murine Models”, Mini-Reviews in Medicinal Chemistry; 21(14) .
Series/Report no.: Mini-Reviews in Medicinal Chemistry;Volume 21 , Issue 14 , 2021
Abstract: Diabetes mellitus is a disease that presents great challenges for healthcare systems worldwide, and the identification of alternative therapies for the treatment of this disease is of vital importance. Metallic nanoparticles (gold, silver, and selenium) and metallic oxide (ZnO) have been studied in different areas such as medicine, biotechnology, the environment, and the food industry with promising results. In medicine, current research has revealed these nanoparticles' anti-diabetic properties thanks to the implementation of animal models. This review will address the existing antecedents and the effects of gold, silver, selenium, and zinc oxide nanoparticles in diabetes administered alone, functionalized with other molecules, or combined with drugs that have shown promising therapeutic effects. The anti-diabetic effects of these nanoparticles are related to the regulation of glucose, insulin, and lipid profiles. In addition, oxidative stress markers, liver and kidney markers, the reduction of inflammation, apoptosis of the pancreas, and the restoration of normal liver and kidney histology are also reported in the literature after using these nanoparticles. However, the therapeutic effects that these nanoparticles provide are limited due to the lack of specific protocols dictated by international organizations to evaluate the risks of using these nanoparticles.
Description: Artículo
ISSN: 1875-5607
Appears in Collections:3201 Artículos

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