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Title: Tumour necrosis factor-alpha polymorphism -308 G/a and its protein in subjects with gingivitis
Authors: Becerra Ruiz, Julieta Sarai
Ramírez De los Santos, Saúl
Alonso Sánchez, Carmen Celina
Martínez Esquivias, Fernando
Martínez Pérez, Luz Andrea
Padilla González, Ana Carolina
Rivera Santana, Gregorio Alejandro
Guerrero Velázquez, Celia
López Pulido, Edgar Iván
Guzmán Flores, Juan Manuel
Keywords: TNF-alpha
periodontal disease
salivary levels
Issue Date: May-2021
Publisher: Taylor and Francis Online
Citation: Becerra Ruiz J.S., Ramírez De los Santos Saúl, Alonso Sánchez C.C., Martínez Esquivias F., Martínez Pérez L.A., Padilla González A.C., Rivera Santana G.A., Guerrero Velázquez C., López Pulido E.I. & Guzmán Flores J.M. (2021) Tumour necrosis factor-alpha polymorphism -308 G/a and its protein in subjects with gingivitis, Acta Odontologica Scandinavica, DOI: 10.1080/00016357.2021.1928280
Series/Report no.: Acta Odontologica Scandinavica;2021
Abstract: AbstractObjective This study examined the association between tumour necrosis factor-alpha (TNF- α) (?308?G/A) polymorphism and gingivitis, and serum and salivary TNF- α levels, in a Mexican population.Material and methods This study enrolled 171 subjects, divided into two groups: healthy subjects and gingivitis patients. TNF- α (?308?G/A) gene polymorphism was analyzed by PCR-RFLP assay. Salivary and serum samples were used to measure cytokine levels through the ELISA technique.Results TNF- α (?308?G/A) polymorphism was shown to have a protective effect in carriers of the A/A genotype and allele A. The G/A genotype is associated with an increase in high-density lipoprotein cholesterol (HDL-C) levels in the gingivitis group. Healthy individuals had higher levels of salivary TNF- α and HDL-C, and increased salivary flow. Triglycerides, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol levels were increased in the gingivitis group. No statistical differences were found in serum TNF- α levels.Conclusion Our data demonstrate that the TNF- α ?308?A/A genotype exerts a protective effect against gingivitis. Moreover, oral conditions are associated with some biochemical parameters.
ISSN: 0001-6357
Appears in Collections:3207 Artículos

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