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Title: Microcephaly, an etiopathogenic vision
Authors: Becerra Solano, Luis Eduardo
Mateos Sanchez, Leovigildo
Lopez Munoz, Eunice
Keywords: acquired microcephaly
congenital microcephaly
isolated microcephaly
microcephaly primary hereditary (MCPH)
Issue Date: Jul-2021
Publisher: ScienceDirect
Citation: Becerra Solano L.E., Mateos Sánchez L., López Muñoz E., (2021). Microcephaly, an etiopathogenic visión. Pediatrics & Neonatology, Volume 62, Issue 4. Pages 354-360. ISSN 1875-9572. DOI:
Series/Report no.: Pediatrics and Neonatology;Vol. 62. Issue 4. (2021) 354-360
Abstract: Microcephaly is defined by an occipital-frontal head circumference (OFD) 2 standard deviations (SD) smaller than the average expected for age, gender and population. Its incidence has been reported between 1.3 and 150 cases per 100,000 births. Currently, new clinical characteristics, causes and pathophysiological mechanisms related to microcephaly continue to be identified. Its etiology is varied and heterogeneous, with genetic and non-genetic factors that produce alterations in differentiation, proliferation, migration, repair of damage to deoxyribonucleic acid and neuronal apoptosis. It requires a multidisciplinary diagnostic approach that includes a medical history, detailed prenatal and postnatal clinical evaluation, cerebral magnetic resonance imaging, neuropsychological evaluation, and in some cases complementary tests such as metabolic screening, tests to rule out infectious processes and genetic testing. There is no specific treatment or intervention to increase cerebral growth; however, timely intervention strategies and programs can be established to improve motor and neurocognitive development, as well as to provide genetic counseling. The objective of this work is to review the available information and reinforce the proposal to carry out an etiopathogenic approach for microcephaly diagnosis and management.
Description: Artículo
ISSN: 1875-9572
Appears in Collections:2412 Artículos

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