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Title: Sex-dependent mechanisms involved in renal tolerance to ischemia-reperfusion: Role of inflammation and histone H3 citrullination
Authors: Melo, Zesergio
Gutiérrez Mercado, Yanet Karina
García Martínez, David
Portilla de Buen, Eliseo
Canales Aguirre, Alejandro A.
González González, Ricardo
Franco Acevedo, Adriana
Palomino, Julio
Echavarría, Raquel
Keywords: ischemia-reperfusion
sexual dimorphism
ovarian hormones
histone citrullination
Issue Date: Dec-2020
Publisher: Elsevier
Citation: Melo Z., Gutierrez-Mercado Y.K., Garcia-Martínez D., Portilla-de-Buen E., Canales-Aguirre A.A., Gonzalez-Gonzalez R., Franco-Acevedo A., Palomino J., Echavarria R. (2020). Sex-dependent mechanisms involved in renal tolerance to ischemia-reperfusion: Role of inflammation and histone H3 citrullination. Transplant Immunology, Volume 63, 101331. ISSN 0966-3274. DOI:
Series/Report no.: Transplant Immunology;Volume 63, December 2020, 101331
Abstract: Abstract Ischemia-reperfusion (I/R) injury, an inevitable result of kidney transplantation, triggers early inflammatory events that affect graft viability. Evidence from human transplantation and preclinical models of I/R suggests that a female hormonal environment positively influences the ability to recover from ischemic injury. However, the mechanisms behind these effects remain mostly unexplored. Here, we studied the influence of sex on pro-inflammatory mediators involved in the pathophysiology of acute I/R injury in male, female, and female ovariectomized (OVX) Wistar rats that underwent unilateral renal ischemia for 45 min, followed by 24 h of reperfusion. We found improved renal function, reduced cytokine expression, and decreased infiltration of myeloperoxidase-positive cells in females after I/R, when compared to their male and female OVX counterparts. Remarkably, citrullination of histone H3 was exacerbated in serum and renal tubules of females after I/R. In contrast, we observed lower levels of citrullinated histone H3 in male and female OVX rats in response to I/R, mostly in neutrophil extracellular traps. Our results demonstrate that female sex promotes renal I/R tolerance by attenuating pro-inflammatory mediators involved in I/R-induced damage.
Description: Artículo
ISSN: 0966-3274
Appears in Collections:2412 Artículos

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