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Title: Distribution of –844 G/A and Hind III C/G PAI-1 Polymorphisms and Plasma PAI-1 Levels in Mexican Subjects: Comparison of Frequencies Between Populations
Authors: Torres Carrillo, Norma
Torres Carrillo, Nora Magdalena
Vázquez del Mercado, Mónica
Rangel Villalobos, Héctor
Parra Rojas, Isela
Sánchez Enríquez, Sergio
Muñoz Valle, José Francisco
Keywords: plasminogen activator inhibitor 1
Mexican subjects
Issue Date: Apr-2008
Publisher: Sage Journals
Citation: Torres-Carrillo, N., Magdalena Torres-Carrillo, N., Vázquez-Del Mercado, M., Rangel-Villalobos, H., Parra-Rojas, I., Sánchez-Enríquez, S., & Francisco Muñoz-Valle, J. (2008). Distribution of —844 G/A and Hind III C/G PAI-1 Polymorphisms and Plasma PAI-1 Levels in Mexican Subjects: Comparison of Frequencies Between Populations. Clinical and Applied Thrombosis/Hemostasis, Vol. 14(2) 220–226.
Series/Report no.: Clinical and Applied Thrombosis/Hemostasis;Volume: 14 issue: 2, page(s): 220-226
Abstract: Several polymorphisms have been described in the PAI-1 gene including the –844 G/A and Hind III C/G polymorphisms. These polymorphisms have been associated with different diseases such as preeclampsia and cardiovascular diseases. The allele and genotype frequencies of both PAI-1 polymorphism where investigated in Mexican subjects and compared with other healthy worldwide populations. The hematological and biochemical parameters where classified according each genotype in our studied group. One hundred Mexican subjects were recruited. Demographic data and hematological and biochemical parameters were collected, and genomic DNA isolation was performed in all the participants. Screening of both polymorphisms studied was made by polymerase chain reaction and restriction analysis. Levels of plasminogen activator inhibitor-1 in plasma were measured by ELISARA plasminogen activator inhibitor antigen kit. The –844 and Hind III genotypes frequencies were as follows: 49% (G/G), 40% (G/A), 11% (A/A) and 50% (C/C), 44% (C/G), 6% (G/G), respectively. The wild-type genotypes (G/G and C/C) were significantly higher with respect to the compared populations. In addition, a significant increase of apolipoprotein A1 in the carriers of G/A –844 and C/G Hind III genotypes was observed. However, when the plasma plasminogen activator inhibitor levels were analyzed with respect to each genotype and haplotype, no significant differences were found.
Description: Artículo
ISSN: 1076296 print
Appears in Collections:3209 Artículos

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