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Title: A Cut-Point Value of Uncarboxylated to Carboxylated Index Is Associated With Glycemic Status Markers in Type 2 Diabetes
Authors: Villafán Bernal, José Rafael
Llamas Covarrubias, Mara Anaís
Muñoz Valle, José Francisco
Rivera León, Edgar Alfonso
González Hita, Mercedes Elvira
Bastidas Ramírez, Blanca Estela
Gurrola Díaz, Carmen Magdalena
Armendáriz Borunda, Juan Socorro
Sánchez Enríquez, Sergio
Keywords: uncarboxylated osteocalcin
glucose metabolism
diabetes mellitus
Issue Date: Jan-2014
Publisher: Journal of Investigative Medicine
Citation: Villafán-Bernal JR, Llamas-Covarrubias MA, Muñoz-Valle JF, et alA Cut-Point Value of Uncarboxylated to Carboxylated Index Is Associated With Glycemic Status Markers in Type 2 DiabetesJournal of Investigative Medicine 2014;62:33-36.
Series/Report no.: Journal of Investigative Medicine;Vol. 62 Num.1. 33-36 pp.
Abstract: Abstract Background The uncarboxylated osteocalcin (ucOC) has been described as a regulator of glucose metabolism in mice, and it is decreased in human type 2 diabetes mellitus (T2D). Although inversely correlated with serum glucose, insulin, and glycated hemoglobin, it is unclear if ucOC decrement is caused by diabetes or plays a role in the pathogenesis and/or progression of the disease. Whatever the case may be, diabetes affects osteoblast gene expression, and possibly the proportion of ucOC over carboxylated OC (cOC). The association of ucOC/cOC index with glycemic status markers in patients with T2D has not been described before. Objective The objective of this study was to assess the ucOC/cOC index and its relationship with glycemic status markers in patients with T2D. Methods The ucOC/cOC index was determined by the quotient of ucOC and cOC serum levels in 80 T2D patients and 160 healthy subjects. The relationship between the ucOC/cOC index and glycemic status markers was evaluated. Results The ucOC/cOC index was low and negatively correlated to fasting plasma glucose and homeostasis assessment-insulin resistance model in T2D patients. The odds ratio for T2D patients with an ucOC/cOC index below the cut-point obtained by receiver operating characteristic analysis was 12.64 (confidence interval, 5.75–27.77; P < 0.001). Conclusions A value of ucOC/cOC index less than 0.3 is associated with markers of poor metabolic control in patients with T2D.
Description: Artículo
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