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Title: Effect of Ursolic Acid on Insulin Resistance and Hyperinsulinemia in Rats with Diet-Induced Obesity: Role of Adipokines Expression
Authors: González Garibay, Angélica S
López Vázquez, Alfonso
García Bañuelos, Jesús
Sánchez Enríquez, Sergio
Sandoval Rodríguez, Ana Soledad
Del Toro Arreola, Susana
Bueno Topete, Miriam Ruth
Muñoz Valle, José Francisco
González Hita, Mercedes Elvira
Domínguez Rosales, José Alfredo
Armendáriz Borunda, Juan Socorro
Bastidas Ramírez, Blanca Estela
Keywords: adiposity
Issue Date: Mar-2020
Publisher: Mary Ann Liebert, Inc., publishers
Citation: Angélica S. González-Garibay, Alfonso López-Vázquez, Jesús García-Bañuelos, Sergio Sánchez-Enríquez, Ana S. Sandoval-Rodríguez, Susana Del Toro Arreola, Miriam R. Bueno-Topete, José F. Muñoz-Valle, Mercedes E. González Hita, José A. Domínguez-Rosales, Juan Armendáriz-Borunda, and Blanca E. Bastidas-Ramírez.Journal of Medicinal Food.Mar 2020.297-304.
Series/Report no.: Journal of Medicinal Food;Vol. 23, No. 3
Abstract: Abstract Excess of visceral adipose tissue (VAT) characteristic of obesity leads to a proinflammatory state disrupting the insulin signaling pathway, triggering insulin resistance (IR) and inflammation, the main processes contributing to obesity comorbidities. Ursolic acid (UA), a pentacyclic triterpenoid occurring in a variety of plant foods, exhibits anti-inflammatory properties. The aim of this study was to evaluate UA effects on IR, hyperinsulinemia, and inflammation in experimental diet-induced obesity. Forty male Wistar rats were randomly assigned to eight groups (n = 5). One group was used for time 0. Three groups were labeled as OBE (control): receiving high-fat diet (HFD; fat content 45.24% of energy) during 3, 6, or 9 weeks; three groups UA-PREV: exposed to simultaneous HFD and UA during 3, 6, or 9 weeks to evaluate UA preventive effects; one group UA-REV: receiving HFD for 6 weeks, followed by simultaneous HFD and UA for three additional weeks to analyze UA reversal effects. Measurements were performed after 3, 6, or 9 weeks of treatment. Adiposity was calculated by weighing VAT after sacrifice. Serum markers were quantified through colorimetric and enzyme-linked immunosorbent assay methods. VAT adipokines RNAm expression was evaluated by quantitative reverse transcriptase–polymerase chain reaction. Data were analyzed by Kruskal–Wallis and Mann–Whitney U tests. UA significantly decreased adiposity, IR, hyperinsulinemia, triacylglycerides, and cholesterol levels, and also VAT mRNA expression of MCP-1 (monocyte chemoattractant protein-1), IL (interleukin)-1β and IL-6, concomitantly increasing adiponectin levels. UA metabolic effects demonstrated in this study support its potential therapeutic utility to improve IR, hyperinsulinemia, and inflammation observed in obesity and diabetes.
Description: Artículo
ISSN: 1096-620X
Appears in Collections:3209 Artículos

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