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Title: Prolactin as immune cell regulator in Toxocara canis somatic larvae chronic infection
Authors: Del Río Araiza, Víctor Hugo
Nava Castro, Karen Elizabeth
Alba Hurtado, Fernando
Quintanar Stephano, Andrés
Aguilar Díaz, Hugo
Muñoz Guzmán, Marco Antonio
Ostoa Saloma, Pedro
Ponce Regalado, María Dolores
Morales Montor, Jorge
Keywords: chronic infection
host-parasite interaction
immune response
Toxocara cannis
Issue Date: Aug-2018
Citation: Víctor Hugo Del Río-Araiza, Karen Elizabeth Nava-Castro, Fernando Alba-Hurtado, Andrés Quintanar-Stephano, Hugo Aguilar-Díaz, Marco Antonio Muñoz-Guzmán, Pedro Ostoa-Saloma, María Dolores Ponce-Regalado, Jorge Morales-Montor; Prolactin as immune cell regulator in Toxocara canis somatic larvae chronic infection. Biosci Rep 31 August 2018; 38 (4): BSR20180305. doi:
Series/Report no.: Bioscience Reports;(2018) 38 (4): BSR20180305
Abstract: Toxocariasis is a zoonotic disease produced by ingestion of larval Toxocara spp. eggs. Prolactin (PRL) has been considered to have an important role in Toxocara canis infection. Recent evidence has found that PRL directly can increase parasite growth and differentiation of T. canis. The present study, evaluated the effect of high PRL levels on the immune system’s response and parasites clearance in chronic infection. Our results showed that hyperprolactinemia did not affect the number of larvae recovered from several tissues in rats. Parasite-specific antibody production, showed no difference between the groups. Lung tissue presented eosinophilic granulomas typical of a chronic infection in all the experimental groups. Flow cytometry analysis was made in order to determine changes in the percentage of innate and adaptive immune cell subpopulations in the spleen, peripheric (PLN) and mesenteric (MLN) lymphatic nodes. The results showed a differential effect of PRL and infection on different immune compartments in the percent of total T cells, T helper cells, T cytotoxic cells, B cells, NK cells, and Tγδ cells. To our knowledge, for the first time it is demonstrated that PRL can have an immunomodulatory role during T. canis chronic infection in the murine host.
Description: Artículo
ISSN: 0144-8463 print
1573-4935 online
Appears in Collections:3212 Artículos

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