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Title: Cysticidal effect of a pure naphthoquinone on Taenia crassiceps cysticerci
Authors: Aranda López, Yuli
López López, Lluvia
Nava Castro, Karen Elizabeth
Ponce Regalado, María Dolores
Becerril Villanueva, Luis Enrique
Girón Pérez, Manuel Iván
Del Río Araiza, Víctor Hugo
Morales Montor, Jorge
Keywords: naphthoquinone
taenia crassiceps
Issue Date: Nov-2021
Publisher: Springer Nature
Citation: Aranda-López, Y., López-López, L., Castro, K.E.N. et al. Cysticidal effect of a pure naphthoquinone on Taenia crassiceps cysticerci. Parasitol Res 120, 3783–3794 (2021).
Series/Report no.: Parasitology Research;Volume 120, issue 11, November 2021
Abstract: Cysticercosis is a disease caused by the metacestode of the parasite Taenia solium (T. solium). In humans, the most severe complication of the disease is neurocysticercosis. The drug of choice to treat this disease is albendazole; however, the bioavailability and efficacy of the drug are variable. Therefore, new molecules with therapeutic effects against this and other parasitic infections caused by helminths must be developed. Naphthoquinones are naphthalene-derived compounds that possess antibacterial, antifungal, antitumoral, and antiparasitic properties. The aim of this work was to evaluate the in vitro anti-helminthic effect of 2-[(3-chlorophenylamino)phenylmethyl]-3-hydroxy-1,4-naphthoquinone, isolated from a natural source and then synthesized (naphthoquinone 4a), using an experimental model of murine cysticercosis caused by Taenia crassiceps (T. crassiceps). This compound causes paralysis in the cysticerci membrane from day 3 of the in vitro treatment. Additionally, it induces changes in the shape, size, and appearance of the cysticerci and a decrease in the reproduction rate. In conclusion, naphthoquinone 4a has in vitro cysticidal activity on T. crassiceps cysticerci depending on the duration of the treatment and the concentration of the compound. Therefore, it is a promising drug candidate to be used in T. crassiceps and possibly T. solium infections.
Description: Artículo
ISSN: 0932-0113 print
1432-1955 online
Appears in Collections:3212 Artículos

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