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Title: Sexual Dimorphism of the Neuroimmunoendocrine Response in the Spleen during a Helminth Infection: A New Role for an Old Player?
Authors: Nava Castro, Karen Elizabeth
Pavón, Lenin
Becerril Villanueva, Luis Enrique
Ponce Regalado, María Dolores
Aguilar Díaz, Hugo
Segovia Mendoza, Mariana
Morales Montor, Jorge
Keywords: helminths
taenia crassiceps
cytokines; immunity
parasite immunity
sexual dimorphism
Issue Date: Mar-2022
Publisher: MDPI
Citation: Nava-Castro, K.E.; Pavón, L.; Becerril-Villanueva, L.E.; PonceRegalado, M.D.; Aguilar-Díaz, H.; Segovia-Mendoza, M.; Morales-Montor, J. Sexual Dimorphism of the Neuroimmunoendocrine Response in the Spleen during a Helminth Infection: A New Role for an Old Player? Pathogens 2022, 11, 308. pathogens11030308
Series/Report no.: Pathogens;2022, 11, 308
Abstract: The interaction of the nervous, immune, and endocrine systems is crucial in maintaining homeostasis in vertebrates, and vital in mammals. The spleen is a key organ that regulates the neuroimmunoendocrine system. The Taenia crassiceps mouse system is an excellent experimental model to study the complex host-parasite relationship, particularly sex-associated susceptibility to infection. The present study aimed to determine the changes in neurotransmitters, cytokines, sex steroids, and sex-steroid receptors in the spleen of cysticercus-infected male and female mice and whole parasite counts. We found that parasite load was higher in females in comparison to male mice. The levels of the neurotransmitter epinephrine were significantly decreased in infected male animals. The expression of IL-2 and IL-4 in the spleen was markedly increased in infected mice; however, the expression of Interleukin (IL)-10 and interferon (IFN)-γ decreased. We also observed sex-associated differences between non-infected and infected mice. Interestingly, the data show that estradiol levels increased in infected males but decreased in females. Our studies provide evidence that infection leads to changes in neuroimmunoendocrine molecules in the spleen, and these changes are dimorphic and impact the establishment, growth, and reproduction of T. crassiceps. Our findings support the critical role of the neuroimmunoendocrine network in determining sex-associated susceptibility to the helminth parasite.
Description: Artículo
ISSN: 2076-0817 Online
2076-0817 (Linking)
Appears in Collections:3212 Artículos

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