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Title: Association between genetic variant rs2267716 of CRHR2 gene with colorectal cancer
Other Titles: BMJ Journals
Authors: Ramírez Guerrero, Angélica Araceli
González Villaseñor, Christian Octavio
Leal Ugarte, Evelia
Gutiérrez Angulo, Melva
Ramírez Flores, Mario
Delgado Enciso, Iván
Macías Gómez, Nelly Margarita
Keywords: colorectal cancer
corticotropin-releasing hormone
Miller method
Issue Date: Apr-2022
Publisher: BMJ Journals. Texas Tech University Health Sciences Center
Citation: Ramírez-Guerrero AA, González-Villaseñor CO, Leal-Ugarte E, et al. Association between genetic variant rs2267716 of CRHR2 gene with colorectal cancer. Journal of Investigative Medicine 2022;70:947-952.
Series/Report no.: Journal of Investigative Medicine;2022;70:947-952.
Abstract: Abstract Colorectal cancer (CRC) is the third most common cancer and one of the main causes of death around the world. Multiple lines of evidence have suggested the role of the corticotropin-releasing hormone (CRH) family in CRC induction, including the low expression of corticotropin-releasing hormone receptor 2 (CRHR2), which is an angiogenesis inhibitor and inflammatory modulator. Previous research suggests that CRHR2 expression in colonic intestinal cells can regulate migration, proliferation and apoptosis through the modulation of several pathways. The aim of this study was to analyze the association of the rs10250835, rs2267716 and rs2267717 variants of CRHR2 gene with CRC in the Mexican population in order to consider its predictive value in CRC. This cross-sectional study included a group of 187 unrelated patients with sporadic CRC and a control group of 191 healthy blood donors. DNA extraction from peripheral blood was carried out using the Miller method. Identification of the rs10250835 variant was performed using PCR-restriction fragment length polymorphism (RFLP) and the rs2267716 and rs2267717 variants using TaqMan allelic discrimination assay. The minor allele homozygous CC of the rs2267716 variant of CRHR2 showed significant difference between CRC and control group (p=0.025), as well as the GCA haplotype (p=0.007), corresponding to the rs10250835, rs2267716 and rs2267717 variants, respectively. Our results suggest that the rs2267716 variant and GCA haplotype of CRHR2 represent a risk factor for CRC development in Mexican patients.
Description: Artículo
ISSN: 1081-5589
1708-8267 online
Appears in Collections:3201 Artículos

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