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Title: Combination effect naringin and pravastatin in lipid profile and glucose in obese rats
Authors: Raffoul Orozco, Abdel Kerim
Ávila González, Ana Elisa
Rodríguez Razón, Christian Martín
García Cobian, Teresa A.
Pérez Guerrero, Edsaul E
García Iglesias, Trinidad
Rubio Arellano, Edy David
Keywords: DM2
Issue Date: Jan-2018
Publisher: Elsevier - Science Direct
Citation: Raffoul-Orozco, A.K., Ávila-González, A.E., Rodríguez-Razón, C.M., García-Cobian, T.A., Pérez-Guerrero, E.E., García-Iglesias, T., Rubio-Arellano, E.D. Combination effect naringin and pravastatin in lipid profile and glucose in obese rats. (2018). Life Sciences, 193, pp. 87-92
Series/Report no.: Life Sciences;Volume 193, Pages 87 - 92
Abstract: Aims The purpose of this study was to compare the effect of naringin 100 mg/kg in combination with pravastatin 10 mg/kg by gavage for 6 weeks compared with monotherapy over lipid profiles, glucose levels and weight in murine model of obesity. Main methods The study design was planned with 5 groups of 6 male Wistar Albina rats: Group 1: control with balanced food and vehicle (C −); Group 2: control with Obesity and vehicle (C +); Group 3: Obesity + naringin (N); Group 4: Obesity + pravastatin (P); Group 5: Obesity + pravastatin + naringin (NP). Obesity was developed with a food model. Key findings The naringin groups showed a decrease in weight gain and low glucose values compared to the control group (weight NP:311.4 vs C +:348.6; glucose NP: 173.12 vs C +:235.56) (p < 0.05); the group with naringin + pravastatin combination showed the total cholesterol (TC), LDL and triglycerides (TGs) to normal levels (TC NP:51.6 vs C +:83.4; LDL NP:9.32 vs C +:32.32; TGs NP:39.4 vs C +:89.4) (p < 0.05); but was not statistically significant compared with monotherapy. Significance The combination of naringin and pravastatin did not appear to be better than monotherapy on lipids, but its use could generate euglycemic and antiobesogenic effects, in addition to diminishing the adverse hepatic effects of pravastatin in rats
Description: Artículo
ISSN: 0024-3205 Print
1879-0631 Online
DOI: 10.1016/j.lfs.2017.11.044
Appears in Collections:3209 Artículos

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