Please use this identifier to cite or link to this item:
Title: Implications of the 5-lipoxygenase allelic variants c.760G>A and -1279 G>T in the nutritional and inflammatory status in Mexican Young Population
Authors: González Torres, Yesica Sughey
González Silva, Napoleón
Villagrán de la Mora, Blanca Zuamí
Guzmán Rodríguez, Luis Felipe
Pérez Reyes, Ángel
Rodríguez Razón, Christian Martín
Colima Fausto, Ana Gabriela
Vargas Becerra, Patricia Noemí
Sánchez Enríquez, Sergio
García García, Maritza Roxana
Keywords: ALOX5 gene
metabolic syndrome
Issue Date: Mar-2019
Publisher: Elsevier - Science Direct
Citation: Gonzalez-Torres, Yesica Sughey et al. (2020). Implications of the 5-lipoxygenase allelic variants c.760G>A and -1279 G>T in the nutritional and inflammatory status in Mexican Young Population. Metabolism - Clinical and Experimental, Volume 104, 154116
Series/Report no.: Metabolism - Clinical and Experimental;Vol. 103, suppl, 154116, March 01, 2020
Abstract: Background: The arachidonate 5-lipoxygenase enzyme (5-LOX), which is encoded by the ALOX5 gene, plays a key role in mediating inflammation. Actually, 5-LOX represents a novel target for prevention of metabolic syndrome. Whether ALOX5 genetic variants associate with 5-LOX activity and pathophysiological events is unclear, and interactions of the allelic variants c.760G>A and -1279 G>T with nutritional and inflammatory status have not been studied in Mexican young population. Objective: The present research examines the ALOX5 gene c.760G>A and -1279 G>T variants and their cross-sectional association with inflammatory and nutritional status. Methods: Young volunteers students between the ages of 18 to 25 years old were recruited in Los Altos University Center. Institutional approval was obtained and all participants gave informed consent. Anthropometrical, biochemical, clinical and dietetic evaluations were performed. Genotyping was realized by Taqman Real-Time PCR Assays. The inflammatory biomarkers IL-6, TNFa and CRP were assayed by ELISA. Results: A total of 549 participants (26% men; 74% women) were studied. The frequency of c.760 G>A showed a significant difference between subjects with high vs normal serum levels of very low density lipoprotein cholesterol (c-VLDL) (p=0.007); moreover, almost significant difference was observed between subjects with high vs normal serum levels of c-LDL (p=0.07). Regarding inflammatory cytokines, a statistical trend was found on the IL-6 serum levels between c.760 G>A genotypes. No significant associations between -1279 G>T genotypes and inflammatory markers were observed. Conclusion: Our findings suggest that the c.760 G>A in the ALOX5 gene could be associated with inflammation and nutritional status.
Description: Artículo
ISSN: 0026-0495
Appears in Collections:3207 Artículos

Files in This Item:
File Description SizeFormat 
Enlace a_Implications of the 5_lipoxygenase allelic variants.htmEnlace a publicación41.12 kBHTMLView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.