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Title: Levels of IL-23/IL-17 Axis in Plasma and Gingival Tissue of Periodontitis Patients According to the New Classification
Authors: Rodríguez Montaño, Ruth
Ruiz Gutiérrez, Alondra del Carmen
Martínez Rodríguez, Vianeth María del Carmen
Gómez Sandoval, Juan Ramón
Guzmán Flores, Juan Manuel
Becerra Ruiz, Julieta Sarai
Zamora Pérez, Ana Lourdes
Guerrero Velázquez, Celia
Keywords: Interleukin-23
Interleukin-23 receptor
Interleukin-17 receptor
Issue Date: Aug-2022
Publisher: MDPI. International Journal of Environmental Research and Public Health
Citation: Rodríguez-Montaño, R.; Ruiz-Gutiérrez, A.d.C.; Martínez-Rodríguez, V.M.d.C.; Gómez-Sandoval, J.R.; Guzmán-Flores, J.M.; Becerra-Ruiz, J.S.; Zamora-Perez, A.L.; Guerrero-Velázquez, C. Levels of IL-23/IL-17 Axis in Plasma and Gingival Tissue of Periodontitis Patients According to the New Classification. Appl. Sci. 2022, 12, 8051. app12168051
Series/Report no.: Appl. Sci.;Vol. 12 (16). 8051
Abstract: Abstract Background: Periodontitis (P) is a chronic inflammatory disease characterized by the destruction of periodontium support tissue generated by different immuno-inflammatory mechanisms, including the RANK/RANKL/OPG and the IL-23/IL-17 axis. Methods: The study was performed with healthy subjects (HS) and patients with periodontitis. Plasma samples were obtained from peripheral blood and the gingival tissue (GT) during periodontal surgery. The ELISA technique was used to evaluate the levels of IL-23, IL-17A, IL-23R, and IL-17RA. Results: In the plasma, a significant decrease in IL-17A was observed in patients with periodontitis than HS. In the GT, IL-23, IL-17A, and IL-17RA levels were increased in periodontitis patients; on the contrary, IL-23R levels were decreased in periodontitis patients when compared with HS. Finally, several positive correlations were found: soluble IL-17RA (sIL-17RA) levels in plasma between the percentage of radiographic bone loss (RBL%), and IL-23 with IL-17A in gingival tissue. Conclusions: The detection of the IL-23/IL-17A axis in gingival tissue and plasma provides us with more information on the behavior of this axis in a localized way in the periodontal microenvironment, in contrast to the systemic levels evaluated according to the new classification of periodontitis.
Description: Artículo
ISSN: 2076-3417
Appears in Collections:3207 Artículos

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