Please use this identifier to cite or link to this item:
Title: Tumor necrosis factor-alpha gene promoter −308G/A and −238G/A polymorphisms in mexican patients with type 2 diabetes mellitus
Authors: Guzmán Flores, Juan Manuel
Muñoz Valle, José Francisco
Sánchez Corona, José
Cobián, José G.
Medina Carrillo, Leopoldo
García Zapién, Alejandra Guadalupe
Cruz Quevedo, Edhit Guadalupe
Flores Martínez, Silvia Esperanza
Keywords: haplotype
mexican patients
type 2 diabetes mellitus
Issue Date: 2011
Publisher: Disease Markers 2011; 30(1): 19–24
Citation: Guzmán-Flores, J. M., Muñoz-Valle, J. F., Sánchez-Corona, J., Cobián, J. G., Medina-Carrillo, L., García-Zapién, A. G.,Cruz-Quevedo, E.G., Flores-Martínez, S. E. (2011). Tumor necrosis factor-alpha gene promoter -308G/A and -238G/A polymorphisms in Mexican patients with type 2 diabetes mellitus. Disease Markers, 30 (1), 19–24.
Abstract: The association between some Tumor necrosis factoralpha (TNF ) promoter polymorphisms and Type 2 diabetes mellitus (T2DM) remains controversial. Ethnic differences may play a role in these conflicting results. The aim of this study was to investigate the association between −308G/A and −238G/A polymorphisms located in the promoter region of the TNF gene and T2DM in Mexican mestizo patients. Nine hundred four individuals (259 patients with T2DM and 645 controls) were genotyped for the −308G/A and −238G/A polymorphisms by PCR–RFLP.We found that the −238A allele increased the risk of developing T2DM in Mexican patients (OR = 1.57, 95% CI: 1.07–2.29; p = 0.018). Moreover, we found that the frequency of the GA haplotype (created by the −308G and −238A alleles) was significantly increased in patients with T2DMwhen compared with controls (OR = 1.56, 95% CI: 1.05–2.31; p = 0.026). Our results suggest that the −238G/A polymorphism and a specific haplotype (GA) are genetic risk factors for the development of T2DM in Mexican population.
ISSN: 0278-0240
Appears in Collections:3207 Artículos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.