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dc.contributor.authorAguilar Hernández, Gabriela-
dc.contributor.authorLópez Romero, Brandon A-
dc.contributor.authorPérez Larios, Alejandro-
dc.contributor.authorRuvalcaba Gómez, José M-
dc.contributor.authorCastellanos Huerta, Inkar-
dc.contributor.authorTellez Isaias, Guillermo-
dc.contributor.authorPetrone García, Victor M-
dc.contributor.authorAnaya Esparza, Luis Miguel-
dc.contributor.authorMontalvo González, Efigenia-
dc.identifier.citationAguilar-Hernández G, López-Romero BA, Pérez-Larios A, Ruvalcaba-Gómez JM, Castellanos-Huerta I, Tellez-Isaias G, Petrone-García VM, Anaya-Esparza LM, Montalvo-González E. Antibacterial Activity of Crude Extract and Purified Acetogenins from Annona muricata Seeds. Applied Sciences. 2023; 13(1):558., en
dc.descriptionArtículoes, en
dc.description.abstractCurrently, several biological activities are attributed to the acetogenins (ACGs) of Annonaceae (including Annona muricata); among these is antimicrobial activity. The main focus of this experiment was to evaluate the antimicrobial effect of the crude extract (CE) and purified acetogenins (P-ACGs) from the endosperm of A. muricata seeds using agar disk diffusion, lethality, sub-lethal, and potential damage membrane tests against Gram-positive and Gram-negative microorganisms. According to the results, P-ACGs present the highest antibacterial effect (12.5–4000 µg/mL) against Enterococcus faecalis (11–15.67 mm), Listeria monocytogenes (12–18 mm), Aeromonas hydrophila (10.33–11.67 mm), Bulkholderia cenocepacia (11–12 mm), and Salmonella paratiphy (11–15.67 mm), and a minimum inhibitory concentration ranging from 0.009 to 12.50 µg/mL. Measurement of the membrane potential shows that, in the presence of P-ACGs, the number of viable cells is reduced, with a significant logarithmic reduction observed (0.38, 1.27, and 1.81 CFU/mL) and a significant sub-lethal lesion (57.78, 96.14, and 98.42%) in Escherichia coli, E. faecalis, and L. monocytogenes, respectively. According to this study, the results demonstrate that P-ACGs from A. muricata seeds are potent and effective antibacterial compounds with potential pharmaceutical, en
dc.language.isoenes, en
dc.publisherMultidisciplinary Digital Publishing Institutees, en
dc.relation.ispartofseriesApplied Sciences;2023, Vol. 13 (1), 558-
dc.subjectA. muricataes, en
dc.subjectseedses, en
dc.subjectacetogeninses, en
dc.subjectnatural extractses, en
dc.subjectantimicrobial activityes, en
dc.titleAntibacterial Activity of Crude Extract and Purified Acetogenins from Annona muricata Seedses, en
dc.typeArticlees, en
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