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DC Field | Value | Language |
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dc.contributor.author | Yáñez Barrientos, Eunice | - |
dc.contributor.author | Barragán Gálvez, Juan Carlos | - |
dc.contributor.author | Hidalgo Figueroa, Sergio | - |
dc.contributor.author | Reyes Luna, Alfonso | - |
dc.contributor.author | González Rivera, Maria L. | - |
dc.contributor.author | Cruz Cruz, David | - |
dc.contributor.author | Isiordia Espinoza, Mario Alberto | - |
dc.contributor.author | Deveze Álvarez, Martha Alicia | - |
dc.contributor.author | Clarisa, Villegas Gómez | - |
dc.contributor.author | Alonso Castro, Ángel Josabad | - |
dc.date.accessioned | 2023-09-08T19:21:16Z | - |
dc.date.available | 2023-09-08T19:21:16Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.citation | Yáñez-Barrientos, E.; Barragan-Galvez, J.C.; Hidalgo-Figueroa, S.; Reyes-Luna, A.; Gonzalez-Rivera, M.L.; Cruz Cruz, D.; Isiordia-Espinoza, M.A.; Deveze-Álvarez, M.A.; Villegas Gómez, C.; Alonso-Castro, A.J. Neuropharmacological Effects of the Dichloromethane Extract from the Stems of Argemone ochroleuca Sweet (Papaveraceae) and Its Active Compound Dihydrosanguinarine. Pharmaceuticals 2023, 16, 1175. https://doi.org/10.3390/ph16081175 | es, en |
dc.identifier.issn | 1424-8247 | - |
dc.identifier.other | https://doi.org/10.3390/ph16081175 | - |
dc.identifier.uri | http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1554 | - |
dc.description | Artículo | es, en |
dc.description.abstract | Argemone ochroleuca Sweet (Papaveraceae) is used in folk medicine as a sedative and hypnotic agent. This study aimed to evaluate the anxiolytic-like, sedative, antidepressant-like, and anticonvulsant activities of a dichloromethane extract of A. ochroleuca stems (AOE), chemically standardized using gas chromatography–mass spectrometry (GC–MS), and its active compound dihydrosanguinarine (DHS). The anxiolytic-like, sedative, antidepressant-like, and anticonvulsant activities of the AOE (0.1–50 mg/kg p.o.) and DHS (0.1–10 mg/kg p.o.) were evaluated using murine models. A possible mechanism for the neurological actions induced by the AOE or DHS was assessed using inhibitors of neurotransmission pathways and molecular docking. Effective dose 50 (ED50) values were calculated by a linear regression analysis. The AOE showed anxiolytic-like activity in the cylinder exploratory test (ED50 = 33 mg/kg), and antidepressant-like effects in the forced swimming test (ED50 = 3 mg/kg) and the tail suspension test (ED50 = 23 mg/kg), whereas DHS showed anxiolytic-like activity (ED50 = 2 mg/kg) in the hole board test. The AOE (1–50 mg/kg) showed no locomotive affectations or sedation in mice. A docking study revealed the affinity of DHS for α2-adrenoreceptors and GABAA receptors. The anxiolytic-like and anticonvulsant effects of the AOE are due to GABAergic participation, whereas the antidepressant-like effects of the AOE are due to the noradrenergic system. The noradrenergic and GABAergic systems are involved in the anxiolytic-like actions of DHS. | es, en |
dc.language.iso | en | es, en |
dc.publisher | MDPI | es, en |
dc.relation.ispartofseries | Pharmaceuticals;2023, 16(8), 1175 | - |
dc.subject | Argemone ochroleuca Sweet | es, en |
dc.subject | anxiolytic | es, en |
dc.subject | antidepressant | es, en |
dc.subject | anticonvulsant | es, en |
dc.title | Neuropharmacological Effects of the Dichloromethane Extract from the Stems of Argemone ochroleuca Sweet (Papaveraceae) and Its Active Compound Dihydrosanguinarine | es, en |
dc.type | Article | es, en |
Appears in Collections: | 3209 Artículos |
Files in This Item:
File | Description | Size | Format | |
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Neuropharmacological Effects of the Dichloromethane Extract.pdf | Documento | 3.7 MB | Adobe PDF | View/Open |
Enlace a_Neuropharmacological Effects of the Dichloromethane Extract .htm | Enlace a publicación | 43.22 kB | HTML | View/Open |
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