Please use this identifier to cite or link to this item: http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1555
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dc.contributor.authorGonzález Rivera, Maria L.-
dc.contributor.authorBarragán Gálvez, Juan Carlos-
dc.contributor.authorGasca Martínez, Deisy-
dc.contributor.authorHidalgo Figueroa, Sergio-
dc.contributor.authorIsiordia Espinoza, Mario Alberto-
dc.contributor.authorAlonso Castro, Ángel Josabad-
dc.date.accessioned2023-09-08T19:21:39Z-
dc.date.available2023-09-08T19:21:39Z-
dc.date.issued2023-04-
dc.identifier.citationGonzalez-Rivera, M.L.; Barragan-Galvez, J.C.; Gasca- Martínez, D.; Hidalgo-Figueroa, S.; Isiordia-Espinoza, M.; Alonso-Castro, A.J. In Vivo Neuropharmacological Effects of Neophytadiene. Molecules 2023, 28, 3457. https://doi.org/ 10.3390/molecules28083457es, en
dc.identifier.issn1420-3049-
dc.identifier.otherhttps://doi.org/10.3390/molecules28083457-
dc.identifier.urihttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1555-
dc.descriptionArtículoes, en
dc.description.abstractNeophytadiene (NPT) is a diterpene found in the methanolic extracts of Crataeva nurvala and Blumea lacera, plants reported with anxiolytic-like activity, sedative properties, and antidepressant-like actions; however, the contribution of neophytadiene to these effects is unknown. This study determined the neuropharmacological (anxiolytic-like, antidepressant-like, anticonvulsant, and sedative) effects of neophytadiene (0.1–10 mg/kg p.o.) and determined the mechanisms of action involved in the neuropharmacological actions using inhibitors such as flumazenil and analyzing the possible interaction of neophytadiene with GABA receptors using a molecular docking study. The behavioral tests were evaluated using the light–dark box, elevated plus-maze, open field, hole-board, convulsion, tail suspension, pentobarbital-induced sleeping, and rotarod. The results showed that neophytadiene exhibited anxiolytic-like activity only to the high dose (10 mg/kg) in the elevated plus-maze and hole-board tests, and anticonvulsant actions in the 4-aminopyridine and pentylenetetrazole-induced seizures test. The anxiolytic-like and anticonvulsant effects of neophytadiene were abolished with the pre-treatment with 2 mg/kg flumazenil. In addition, neophytadiene showed low antidepressant effects (about 3-fold lower) compared to fluoxetine. On other hand, neophytadiene had no sedative or locomotor effects. In conclusion, neophytadiene exerts anxiolytic-like and anticonvulsant activities with the probable participation of the GABAergic system.es, en
dc.language.isoenes, en
dc.publisherMDPIes, en
dc.relation.ispartofseriesMolecules;2023, 28(8), 3457-
dc.subjectneophytadienees, en
dc.subjectanxietyes, en
dc.subjectconvulsiones, en
dc.subjectditerpenees, en
dc.titleIn Vivo Neuropharmacological Effects of Neophytadienees, en
dc.typeArticlees, en
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