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Title: Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis
Other Titles: Special Issue Periodontal Diseases and Oral Health
Authors: Isiordia Espinoza, Mario Alberto
Gómez Sánchez, Eduardo
Mora Falcón, Itzel Joselyn
Amador Beas, Iván Agustín
Hernández Gómez, Adriana
Serafín Higuera, Nicolás Addiel
Franco de la Torre, Lorenzo
Keywords: analgesic efficacy
COX-2 inhibitors
non-steroidal anti-inflammatory analgesics
periodontal surgery
Issue Date: Apr-2023
Publisher: MDPI
Citation: Isiordia-Espinoza MA, Gómez-Sánchez E, Mora-Falcón IJ, Amador-Beas IA, Hernández-Gómez A, Serafín-Higuera NA, Franco-de la Torre L. Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis. Healthcare (Basel). 2023 Apr 6;11(7):1054. doi: 10.3390/healthcare11071054. PMID: 37046983; PMCID: PMC10093797.
Series/Report no.: Healthcare;2023, 11(7), 1054
Abstract: The objective of this systematic review and meta-analysis was to evaluate the analgesic efficacy of COX-2 inhibitors versus other drugs in periodontal surgery. Two researchers searched PubMed, Google Scholar, ACM Digital, BASE, EBSCOhost, Scopus, or Web of Science for clinical trials using various combinations of words. All articles that met the selection criteria were assessed using the Cochrane Collaboration’s risk of bias tool. For data analysis, the inverse variance and mean difference statistical method was used with Review Manager 5.3 software for Windows. According to the conclusion of each study (qualitative evaluation), only one clinical trial had results in favor of a COX-2 inhibitor when compared to placebo, one clinical study informed that a COX-2 was better that an active control, four studies showed similar analgesic efficacy to active controls, and one clinical study informed the analgesic effect of one celecoxib-caffeine combination in comparison with celecoxib alone and placebo (n = 337). The COX-2 inhibitors showed a decrease in the rescue analgesic consumption (n = 138; I2 = 15%; mean difference = −0.31; 95%CIs = −0.6 to −0.01), and lower pain intensity at four hours (n = 178; I2 = 0%; mean difference = −2.25; 95%CIs = −2.94 to −1.55; p = 0.00001) when compared to active controls after periodontal surgery. In conclusion, the data indicate that COX-2 agents produce better pain relief in comparison to placebo and other drugs after periodontal surgery.
Description: Artículo
ISSN: 2227-9032
Appears in Collections:3209 Artículos

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