Please use this identifier to cite or link to this item:
Title: Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources
Authors: Anaya Esparza, Luis Miguel
Aurora Vigo, Edward F.
Villagrán de la Mora, Blanca Zuamí
Rodríguez Lafitte, Ernesto
Ruvalcaba Gómez, José Martín
Solano Cornejo, Miguel Ángel
Zamora Gasga, Victor Manuel
Montalvo González, Efigenia
Gómez Rodríguez, Horacio
Aceves Aldrete, César Eduardo
González Silva, Napoleón
Keywords: ultrasound
phenolic compounds
green extraction
mathematical models
desirability function
Issue Date: Dec-2023
Publisher: MDPI
Citation: Anaya-Esparza, L.M.; Aurora-Vigo, E.F.; Villagrán, Z.; Rodríguez-Lafitte, E.; Ruvalcaba -Gómez, J.M.; Solano-Cornejo, M.Á.; Zamora-Gasga, V.M.; Montalvo -González, E.; Gómez-Rodríguez, H.; Aceves-Aldrete, C.E.; et al. Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources. Molecules 2023, 28, 7752. molecules28237752
Series/Report no.: Molecules;2023, 28, 7752
Abstract: Plant-based materials are an important source of bioactive compounds (BC) with interesting industrial applications. Therefore, adequate experimental strategies for maximizing their recovery yield are required. Among all procedures for extracting BC (maceration, Soxhlet, hydro-distillation, pulsed-electric field, enzyme, microwave, high hydrostatic pressure, and supercritical fluids), the ultrasound-assisted extraction (UAE) highlighted as an advanced, cost-efficient, eco-friendly, and sustainable alternative for recovering BC (polyphenols, flavonoids, anthocyanins, and carotenoids) from plant sources with higher yields. However, the UAE efficiency is influenced by several factors, including operational variables and extraction process (frequency, amplitude, ultrasonic power, pulse cycle, type of solvent, extraction time, solvent-to-solid ratio, pH, particle size, and temperature) that exert an impact on the molecular structures of targeted molecules, leading to variations in their biological properties. In this context, a diverse design of experiments (DOEs), including full or fractional factorial, Plackett–Burman, Box-Behnken, Central composite, Taguchi, Mixture, D-optimal, and Doehlert have been investigated alone and in combination to optimize the UAE of BC from plant-based materials, using the response surface methodology and mathematical models in a simple or multi-factorial/multi-response approach. The present review summarizes the advantages and limitations of the most common DOEs investigated to optimize the UAE of bioactive compounds from plant-based materials.
Description: Artículo
ISSN: 1420-3049
Appears in Collections:3309 Artículos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.