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Title: Celecoxib Decreases the Need for Rescue Analgesics after Total Knee Arthroplasty: A Meta-Analysis
Authors: Gómez Sánchez, Eduardo
Hernández Gómez, Adriana
Guzmán Flores, Juan Manuel
Alonso Castro, Angel Josabad
Serafín Higuera, Nicolás Addiel
Balderas Peña, Luz Ma. Adriana
Franco de la Torre, Lorenzo
Isiordia Espinoza, Mario Alberto
Keywords: celecoxib
analgesic efficacy
adverse effects
total knee arthroplasty
Issue Date: Apr-2024
Publisher: MDPI
Citation: Gómez-Sánchez, E.; Hernández-Gómez, A.; Guzmán-Flores, J.M.; Alonso-Castro, A.J.; Serafín-Higuera, N.A.; Balderas-Peña, L.M.-A.; Franco-de la Torre, L.; Isiordia-Espinoza, M.A. Celecoxib Decreases the Need for Rescue Analgesics after Total Knee Arthroplasty: A Meta-Analysis. Clin. Pract. 2024, 14, 461–472. https://
Series/Report no.: Clinics and Practices;2024, 14(2), 461-472
Abstract: This systematic review and meta-analysis aimed to evaluate the analgesic efficacy and adverse effects of celecoxib after total knee arthroplasty. Keywords in the PubMed and Scopus databases were used to find article abstracts. Each included clinical trial was assessed using the Cochrane Collaboration risk of bias tool, and we extracted data on postoperative pain assessment using the Visual Analogue Scale (VAS) at rest, ambulation, and active range of motion, rescue analgesic intake, and adverse effects. Inverse variance tests with mean differences were used to analyze the numerical variables. The Mantel–Haenszel statistical method and the odds ratio were used to evaluate the dichotomous data. According to this qualitative assessment (n = 482), two studies presented conclusions in favor of celecoxib (n = 187), one showed similar results between celecoxib and the placebo (n = 44), and three clinical trials did not draw conclusions as to the effectiveness of celecoxib versus the placebo (n = 251). Moreover, the evaluation of the rescue analgesic intake showed that the patients receiving celecoxib had a lower intake compared to patients receiving a placebo (n = 278, I2 = 82%, p = 0.006, mean difference = −6.89, 95% IC = −11.76 to −2.02). In conclusion, the pooled analysis shows that administration of celecoxib alone results in a decrease in rescue analgesic consumption compared to a placebo after total knee surgery.
Description: Artículo
ISSN: 2039-7283
Appears in Collections:5309 Artículos

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