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Title: Prolactin and Prolactin Receptor Expression In Cervical Intraepithelial Neoplasia and Cancer
Authors: López Pulido, Edgar Iván
Ascencio Cedillo, Rafael
Pereira Suárez, Ana Laura
Muñoz Valle, José Francisco
Villegas Sepúlveda, Nicolás
Del Toro Arreola, Susana
Estrada Chávez, Ciro
Daneri Navarro, Adrian
Franco Topete, Ramón
Pérez Montiel, Delia
García Carrancá, Alejandro
Keywords: cervical cancer
prolactin receptor
Issue Date: 2014
Publisher: Pathology & Oncology Research
Citation: Ascencio-Cedillo, R., López-Pulido, E. I., Muñoz-Valle, J. F., Villegas-Sepúlveda, N., Del Toro-Arreola, S., Estrada-Chávez, C., Pereira-Suárez, A. L. (2014). Prolactin and Prolactin Receptor Expression in Cervical Intraepithelial Neoplasia and Cancer. Pathology Oncology Research. doi:10.1007/s12253-014-9814-6
Abstract: Prolactin receptor (PRLR) overexpression could play a role in tumorigenesis. The aim of this study was to determine prolactin (PRL) and PRLR expression in biopsies from patients with precursor lesions and uterine cervical cancer. PRLR expression was analyzed in 63 paraffin-embedded biopsies of uterine cervical tissue. In total, eleven low-grade squamous intraepithelial lesions (LSIL), 23 high-grade squamous intraepithelial lesions (HSIL), 21 uterine cervical cancers (UCC) and 8 normal epithelium (NE) were examined using immunoperoxidase staining and Western blot analysis. Additionally, PRL expression was identified in human cervical cancer serum and tissues. The PRLR expression was found to be significantly increased in cervical cancer in comparison with normal tissue and precursor lesions (P < 0.0003). The presence of the long isoform of the PRLR was observed only in cervical cancer tissues. Serum PRL levels were normal in all samples and local prolactin expression was similar in precursor lesions and cervical cancer by Western blot analysis. Our data suggest a possible role for PRLR in the progression of cervical cancer.
ISSN: 1532-2807
Appears in Collections:2407 Artículos

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