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Title: Associations of killer cell immunoglobulinlike receptor genes with rheumatoid arthritis
Authors: Ramírez De los Santos, Saúl
Sánchez Hernández, Pedro Ernesto
Muñoz Valle, José Francisco
Palafox Sánchez, Claudia Azucena
Rosales Rivera, Lizet Yadira
García Iglesias, Trinidad
Daneri Navarro, Adrian
Ramírez Dueñas, María Guadalupe
Keywords: KIR
killer cell immunoglobulin-like receptor
natural killer cell receptors
rheumatoid arthritis
autoimmune disease
Issue Date: 2012
Publisher: Disease Markers. Volume 33 (2012), Issue 4, Pages 201-206
Citation: Ramírez-De los Santos, S., Sánchez-Hernández, P. E., Muñoz-Valle, J. F., Palafox-Sánchez, C. a, Rosales-Rivera, L. Y., García-Iglesias, T., … Ramírez-Dueñas, M. G. (2012). Associations of killer cell immunoglobulin- like receptor genes with rheumatoid arthritis. Disease Markers, 33(4), 201–6. doi:10.3233/DMA-2012-0927
Abstract: Objective: Rheumatoid Arthritis (RA) is an autoimmune and chronic inflammatory disease of unknown etiology. Killer cell immunoglobulin-like receptors are expressed on the surface of natural killer cells and CD28null T-cells, both present in synovial membrane of RA. Therefore we evaluated the associations of KIR genes with RA. Methods: 16 KIR genes were genotyped in 100 healthy subjects (HS) and 100 RA patients fromWestern Mexico using PCR-SSP. Differences in KIR genotypes and gene frequencies were assessed using the X2 test. Results: Gene frequency of KIR2DL3 was lower in RA than in HS (p = 0.0019), whereas KIR2DL2 and KIR2DS2 were higher in RA than HS (p = 0.0004 and p = 0.0487, respectively). In addition were identified 38 genotypes (from G1-G38) in both studied groups, and the genotype frequencies of G1, G6 and G14 showed significant differences (p = 0.0001, p = 0.0208 and p = 0.0300, respectively). Conclusions: The presence of KIR2DL2, KIR2DS2 and absence of KIR2DL3 are associated with RA. Moreover, two genotypes BX are associated with RA. These results suggest that KIRs can be involved in RA susceptibility.
ISSN: 0278-0240
Appears in Collections:3201 Artículos

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