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Title: MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer
Authors: Muñiz Mendoza, Rodolfo
Ayala Madrigal, María de la Luz
Partida Pérez, Miriam
Peregrina Sandoval, Jorge
Leal Ugarte, Evelia
Macías Gómez, Nelly
Peralta Leal, Valeria
Meza Espinoza, Juan Pablo
Moreno Ortiz, José Miguel
Ramírez Ramírez, Ruth
Suárez Villanueva, Alexis Sayuri
Gutiérrez Angulo, Melva
Keywords: MLH1 gene
XRCC1 gene
colorectal cancer
mexican population
Issue Date: Jun-2012
Publisher: Fundação de Pesquisas Científicas de Ribeirão Preto. Brasil.
Citation: Muñiz-Mendoza, R., Ayala-Madrigal, M. L., Partida-Pérez, M., Peregrina-Sandoval, J., Leal-Ugarte, E., Macías-Gómez, N., … Gutiérrez-Angulo, M. (2012). MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer. Genetics and Molecular Research, 11(3), 2315–2320. Retrieved from
Series/Report no.: Genetics and Molecular Research;11 (3): 2315 - 2320
Abstract: DNA repair proteins maintain DNA integrity; polymorphisms in genes coding for these proteins can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in Mexican patients. Genomic DNA samples were obtained from peripheral blood of 108 individuals with CRC (study group) at diagnosis and 120 blood donors (control group) from Western Mexico; both groups were mestizos. The polymorphisms were detected by PCR-RFLP. Association was estimated by calculating the odds ratio (OR). We found that the MLH1 and XRCC1 polymorphisms were in Hardy-Weinberg equilibrium. The MLH1 655A>G polymorphism in the 655G allele was associated with a 2-fold increase risk for CRC (OR = 2.04 and 95% confidence interval (95%CI) = 1.12-3.69; P < 0.01), while the MLH1 -93G>A polymorphism allele was associated with a protective effect (OR = 0.60, 95%CI = 0.40-0.89; P = 0.01 in the -93A allele and OR = 0.32, 95%CI = 0.13-0.79; P = 0.01 in the AA genotype). The XRCC1 Arg194Trp and Arg399Gln polymorphisms did not show any significant associations. In conclusion, we found that MLH1 -93G>A and 655A>G polymorphisms are associated with CRC in Mexican patients.
ISSN: 1676-5680
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