A t(1;9)(q23.3~q25;q34) affecting the ABL1 gene in a biphenotypic leukemia.

Centro Universitario de los Altos

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Title:	A t(1;9)(q23.3~q25;q34) affecting the ABL1 gene in a biphenotypic leukemia.
Other Titles:	Short communication
Authors:	González García, Juan Ramón Bohlander, Stefan K. Gutiérrez Angulo, Melva Esparza Flores, María Amparo Picos Cárdenas, Verónica Judith Meza Espinoza, Juan Pablo Ayala Madrigal, María de la Luz Rivera, Horacio
Issue Date:	2004
Publisher:	Elsevier Inc.
Series/Report no.:	Cancer Genetics and Cytogenetics;152 (2004) 81–83
Abstract:	Recurring chromosome translocations, which are found in leukemia, can result in the inappropriate expression of oncogenes or in the formation of chimeric genes that code for structurally and functionally abnormal proteins. The chromosomal t(1;9)(q23.3~q25;q34) was found in a patient with biphenotypic leukemia. Fluorescence in situ hybridization (FISH) analysis revealed that the break on chromosome 9 occurred in the ABL1 gene. The breakpoint on chromosome 1 occurred distal to the PBX1 gene at 1q23.3, as shown by FISH using BAC RP11-503N16 and RP11-403P14, which flank the PBX1 locus; hence, the ABL1 gene can be fused with another gene distal to PBX1 gene.
URI:	http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/375
ISSN:	0165-4608
Appears in Collections:	2409 Artículos

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