Please use this identifier to cite or link to this item:
Title: A t(1;9)(q23.3~q25;q34) affecting the ABL1 gene in a biphenotypic leukemia.
Other Titles: Short communication
Authors: González García, Juan Ramón
Bohlander, Stefan K.
Gutiérrez Angulo, Melva
Esparza Flores, María Amparo
Picos Cárdenas, Verónica Judith
Meza Espinoza, Juan Pablo
Ayala Madrigal, María de la Luz
Rivera, Horacio
Issue Date: 2004
Publisher: Elsevier Inc.
Series/Report no.: Cancer Genetics and Cytogenetics;152 (2004) 81–83
Abstract: Recurring chromosome translocations, which are found in leukemia, can result in the inappropriate expression of oncogenes or in the formation of chimeric genes that code for structurally and functionally abnormal proteins. The chromosomal t(1;9)(q23.3~q25;q34) was found in a patient with biphenotypic leukemia. Fluorescence in situ hybridization (FISH) analysis revealed that the break on chromosome 9 occurred in the ABL1 gene. The breakpoint on chromosome 1 occurred distal to the PBX1 gene at 1q23.3, as shown by FISH using BAC RP11-503N16 and RP11-403P14, which flank the PBX1 locus; hence, the ABL1 gene can be fused with another gene distal to PBX1 gene.
ISSN: 0165-4608
Appears in Collections:2409 Artículos

Files in This Item:
File Description SizeFormat 
Enlace a_A t(1;9).htmEnlace a publicación24.06 kBHTMLView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.