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Title: Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients.
Authors: Partida Pérez, Miriam
Ayala Madrigal, María de la Luz
Peregrina Sandoval, Jorge
Macías Gómez, Nelly
Moreno Ortiz, José Miguel
Leal Ugarte, Evelia
Cárdenas Meza, Mario
Centeno Flores, Manuel
Maciel Gutiérrez, Víctor
Cabrales, Enrique
Cervantes Ortiz, Sergio
Gutiérrez Angulo, Melva
Issue Date: 2010
Series/Report no.: Cancer Biomarkers;vol. 7, no. 3, 2010, pp. 117-121
Abstract: Leptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the former stimulate whereas the latter inhibit it. The objective was to analyze the association of LEP A19G and ADIPOQ+45 T/G and +276 G/T polymorphisms in Mexican patients with colorectal cancer (CRC). 68 unrelated patients with CRC (study group) and 102 blood donors (control group); all subjects were Mestizos from western Mexico. The polymorphisms were established by PCR-RFLP on DNA samples obtained from peripheral blood. The LEP A19G polymorphism showed significant differences between CRC patients and control group (p= 0.01 for G/A genotype and p= 0.02 for the recessive model G/G +G/A); yet, in the analysis stratified by gender, this difference remained significant only in males. The ADIPOQ polymorphisms did not shown any significant differences. Our results suggest that the A19G LEP polymorphism is associated with CRC in Mexican patients.
ISSN: 1574-0153 (P)
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