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Title: Assessment of the antinociceptive and ulcerogenic activity of the tapentadol–diclofenac combination in rodents
Authors: Zapata Morales, Juan Ramón
Alonso Castro, Ángel Josabad
Granados Soto, Vinicio
Sánchez Enríquez, Sergio
Isiordia Espinoza, Mario Alberto
Keywords: acetic acid-induced writhing test
antinociceptive synergistic interaction
gastrointestinal damage
Issue Date: Feb-2018
Publisher: Wiley Online Library
Citation: Zapata Morales J.R., Alonso Castro A.J., Granados Soto V., Sánchez Enriquez S., Isiordia Espinoza M.A. (2018). Assessment of the antinociceptive and ulcerogenic activity of the tapentadol–diclofenac combination in rodents. Drug Dev. Res. 2018;79:38–44.
Series/Report no.: Drug Development Research;Vol. 79; 1
Abstract: Abstract The objective of the present study was to evaluate the tapentadol–diclofenac combination in three dose-ratios in the mouse acetic acid-induced visceral pain and their ulcerogenic activity on the stomachal mucous. Dose-response curves were generated for tapentadol, diclofenac, and their combination in the acetic acid-induced writhing test in mice. Moreover, the stomachs of animals were surgically removal and gastrointestinal ulcerogenic action of the combination was assessed. The isobolographic analysis, interaction index, and ANOVA were used to analyze the data. The isobolographic analysis and interaction index showed a similar antinociceptive activity for the three combinations of the analgesic mixture. Moreover, tapentadol and the proportions 1:1 or 3:1 of the analgesic combination caused a mild gastrointestinal damage. These data indicate that the systemic co-administration of tapentadol and diclofenac produced a synergistic interaction in the acetic acid-induced visceral pain test with an acceptable gastric damage profile in mice.
ISSN: 1098-2299
Appears in Collections:3209 Artículos

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