Please use this identifier to cite or link to this item:
Title: Chronic infection with Mycobacterium lepraemurium induces alterations in the hippocampus associated with memory loss
Authors: Becerril Villanueva, Luis Enrique
Ponce Regalado, María Dolores
Pérez Sánchez, Gilberto
Salazar Juárez, Alberto
Arreola, Rodrigo
Álvarez Sánchez, María Elizbeth
Juárez Ortega, Mario
Falfán Valencia, Ramcés
Hernández Pando, Rogelio
Morales Montor, Jorge
Pavón, Lenin
Rojas Espinosa, Oscar
Keywords: mycobacterium lepraemurium
human leprosy
memory deterioration
Issue Date: 13-Jun-2018
Publisher: Nature Research
Citation: Becerril Villalnueva, E. et. al. (2018) Chronic infection with Mycobacterium lepraemurium induces alterations in the hippocampus associated with memory loss. Scientific Reports. Vol. 8:9063
Series/Report no.: Scientific Reports.;Vol. 8:9063
Abstract: Murine leprosy, caused by Mycobacterium lepraemurium (MLM), is a chronic disease that closely resembles human leprosy. Even though this disease does not directly involve the nervous system, we investigated a possible effect on working memory during this chronic infection in Balb/c mice. We evaluated alterations in the dorsal region of the hippocampus and measured peripheral levels of cytokines at 40, 80, and 120 days post-infection. To evaluate working memory, we used the T-maze while a morphometric analysis was conducted in the hippocampus regions CA1, CA2, CA3, and dentate gyrus (DG) to measure morphological changes. In addition, a neurochemical analysis was performed by HPLC. Our results show that, at 40 days post-infection, there was an increase in the bacillary load in the liver and spleen associated to increased levels of IL-4, working memory deterioration, and changes in hippocampal morphology, including degeneration in the four subregions analyzed. Also, we found a decrease in neurotransmitter levels at the same time of infection. Although MLM does not directly infect the nervous system, these findings suggest a possible functional link between the immune system and the central nervous system.
URI: DOI:10.1038/s41598-018-27352-x
ISSN: 2045-2322
Appears in Collections:3205 Artículos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.