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Title: Association of A-604G ghrelin gene polymorphism and serum ghrelin levels with the risk of obesity in a mexican population
Authors: Llamas Covarrubias, Iris Monserrat
Llamas Covarrubias, Mara Anaís
Martinez López, Erika
Zepeda Carrillo, Eloy Alfonso
Rivera León, Edgar Alfonso
Palmeros Sánchez, Beatriz
Alcalá Zermeño, Juan Luis
Sánchez Enríquez, Sergio
Keywords: obesity
Issue Date: Jul-2017
Publisher: Kluwer Academic Publishers
Citation: Llamas Covarrubias I.M., Llamas Covarrubias M.A., Martinez López E., Zepeda Carrillo E.A., Rivera León E.A., Palmeros Sánchez B., Alcalá Zermeño J.L. y Sánchez Enríquez S. (2017). Association of A-604G ghrelin gene polymorphism and serum ghrelin levels with the risk of obesity in a mexican population. Molecular Biology Reports. Vol. 44, núm. 3, pp: 289-293
Series/Report no.: Molecular Biology Reports;Vol. 44, núm. 3
Abstract: Obesity is a metabolic disorder that has a multifactorial etiology and affects millions of people worldwide. Ghrelin, a hormone coded by the GHRL gene, plays a role in human body composition and appetite. Single nucleotide polymorphisms (SNPs) of the GHRL gene have been associated with obesity and metabolic disorders. To evaluate the association of A-604G SNP of GHRL promoter region with serum ghrelin levels and the risk of obesity in a Mexican population. Two hundred and fifty individuals were enrolled and classified as obese or control subjects (CS) according to BMI. DNA samples, anthropometric measurements and biochemical parameters were obtained from all subjects. The A-604G SNP was genotyped using PCR-RFLPs technique. Ghrelin levels were measured using a commercial enzyme immunoassay. The G/G genotype was more frequent among obese individuals (p<0.0001) when compared to CS. The G/A genotype and A allele were associated with protection against obesity (OR 0.29, p<0.0001; OR 0.39, p<0.0001 respectively), the A allele remained significant after adjusting for age and gender (OR: 0.25, p<0.0001). Serum ghrelin levels were higher in obese patients (p=0.004) than in CS, however, significance was lost after adjustment for age (p=0.088). The G/G genotype was associated with higher levels of serum ghrelin (p=0.02) independently of the effect of age. The G/G genotype of the A-604G SNP in the GHRL gene is associated with altered serum ghrelin levels and obesity. The A allele was also associated with protection against obesity in this study
URI: doi.10.1007/s11033-017-4109-0
ISSN: 0301-4851
Appears in Collections:3209 Artículos

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