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Title: Cardiovascular Risk Factors in Adolescents: Role of Insulin Resistance and Obesity.
Authors: López Sandoval, J.
Sánchez Enríquez, Sergio
Rivera León, Edgar Alfonso
Bastidas Ramírez, Blanca Estela
García García, M.R.
González Hita, Mercedes
Keywords: adolescents
body fat
cardiovascular risk
Issue Date: Sep-2018
Publisher: The International Journal of Romanian Society of Endocrinology
Citation: Lopez Sandoval, J. (2018) Cardiovascular risk factors in adolescents: role of insulin resistance and obesity. Acta Endocrinologica(Bucharest) 2018 14: 330-337
Series/Report no.: Acta Endocrinologica (Bucharest);2018: 14
Abstract: Introduction. Childhood obesity is a public health problem characterized by early insulin resistance (IR), inflammation, and oxidative stress. The presence of an uninterrupted low-grade inflammatory state impairs metabolic and cardiovascular health. The population is particularly susceptible to develop metabolic disorders related to increased body fat. Methods. Eighty-three adolescents were recruited and grouped according to HOMA-IR and BMI in either with or without IR and obese or normal-weight respectively. Anthropometric, biochemical, immunological and hormonal variables were determined. Transverse Analytical Study. Results. Obesity, dyslipidemia, IL-6, and C-reactive protein were significantly higher in the IR group than in the non-IR group. Obese adolescents showed increased insulin levels, HOMA-IR, inflammatory markers, and triglycerides; while having lower HDL-C, and adiponectin when compared to normal-weight adolescents. As expected, obesity-related anthropometric markers positively correlated with IR and inflammatory markers while negatively correlated with adiponectin levels. Conclusions. Early IR, subclinical inflammation, dyslipidemia, and hypoadiponectinemia characterize obesity in adolescents. These factors may increase the risk of future coronary heart disease (CHD) and diabetes mellitus development (DM) in early adulthood.
ISSN: 1841-0987
Appears in Collections:3209 Artículos

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